H
Hiroshi Ikegami
Researcher at Kindai University
Publications - 257
Citations - 10773
Hiroshi Ikegami is an academic researcher from Kindai University. The author has contributed to research in topics: Diabetes mellitus & Type 1 diabetes. The author has an hindex of 48, co-authored 245 publications receiving 9812 citations. Previous affiliations of Hiroshi Ikegami include Osaka University & Aichi Gakuin University.
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Journal ArticleDOI
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms
Junichi Miyazaki,Kimi Araki,Eiji Yamato,Hiroshi Ikegami,Tomoichiro Asano,Yoshikazu Shibasaki,Yoshitomo Oka,Ken Ichi Yamamura +7 more
TL;DR: The MIN6 cell line will be especially useful to analyze the molecular mechanisms by which beta cells regulate insulin secretion in response to extracellular glucose concentrations, and a possible role of GT isoforms in glucose sensing by beta cells is discussed.
Journal ArticleDOI
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Anubha Mahajan,Min Jin Go,Weihua Zhang,Jennifer E. Below,Kyle J. Gaulton,Teresa Ferreira,Momoko Horikoshi,Andrew D. Johnson,Maggie C.Y. Ng,Inga Prokopenko,Inga Prokopenko,Danish Saleheen,Xu Wang,Eleftheria Zeggini,Gonçalo R. Abecasis,Linda S. Adair,Peter Almgren,Mustafa Atalay,Tin Aung,Tin Aung,Damiano Baldassarre,Beverley Balkau,Beverley Balkau,Yuqian Bao,Anthony H. Barnett,Anthony H. Barnett,Inês Barroso,Inês Barroso,Inês Barroso,Abdul Basit,Latonya F. Been,John Beilby,John Beilby,Graeme I. Bell,Rafn Benediktsson,Richard N. Bergman,Bernhard OBoehm,Bernhard OBoehm,Eric Boerwinkle,Eric Boerwinkle,Lori L. Bonnycastle,Noël P. Burtt,Qiuyin Cai,Harry Campbell,Jason Carey,Stéphane Cauchi,Mark J. Caulfield,Juliana C.N. Chan,Li Ching Chang,Tien-Jyun Chang,Yi-Cheng Chang,Guillaume Charpentier,Chien-Hsiun Chen,Chien-Hsiun Chen,Han Chen,Yuan-Tsong Chen,Kee Seng Chia,Manickam Chidambaram,Peter S. Chines,Nam H. Cho,Young Min Cho,Lee-Ming Chuang,Francis S. Collins,Marilyn C. Cornelis,David Couper,Andrew Crenshaw,Rob M. van Dam,Rob M. van Dam,John Danesh,Debashish Das,Ulf de Faire,George Dedoussis,Panos Deloukas,Antigone S. Dimas,Christian Dina,Christian Dina,Alex S. F. Doney,Peter Donnelly,Mozhgan Dorkhan,Cornelia M. van Duijn,Josée Dupuis,Josée Dupuis,Sarah Edkins,Paul Elliott,Paul Elliott,Valur Emilsson,Raimund Erbel,Johan G. Eriksson,Jorge Escobedo,Tõnu Esko,Tõnu Esko,Elodie Eury,Jose C. Florez,Jose C. Florez,Pierre Fontanillas,Nita G. Forouhi,Tom Forsén,Caroline S. Fox,Caroline S. Fox,Ross M. Fraser,Timothy M. Frayling,Philippe Froguel,Philippe Froguel,Philippe M. Frossard,Yu-Tang Gao,Karl Gertow,Christian Gieger,Bruna Gigante,Harald Grallert,George B. Grant,Leif Groop,Christopher J. Groves,Elin Grundberg,Elin Grundberg,Elin Grundberg,Candace Guiducci,Anders Hamsten,Bok Ghee Han,Hara Kazuo,Neelam Hassanali,Andrew T. Hattersley,Caroline Hayward,Åsa K. Hedman,Christian Herder,Albert Hofman,Oddgeir L. Holmen,Kees Hovingh,Astradur B. Hreidarsson,Cheng Hu,Frank B. Hu,Jennie Hui,Jennie Hui,Steve E. Humphries,Sarah E. Hunt,David J. Hunter,Kristian Hveem,Zafar I. Hydrie,Hiroshi Ikegami,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Muhammed Islam,Bo Isomaa,Anne U. Jackson,Tazeen H. Jafar,Alan James,Alan James,Weiping Jia,Karl-Heinz Jöckel,Anna Jonsson,Jeremy B M Jowett,Takashi Kadowaki,Hyun Min Kang,Stavroula Kanoni,Wen Hong L. Kao,Sekar Kathiresan,Sekar Kathiresan,Norihiro Kato,Prasad Katulanda,Prasad Katulanda,Sirkka Keinänen-Kiukaanniemi,Ann M. Kelly,Ann M. Kelly,Hassan Khan,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Hyung Lae Kim,Sangsoo Kim,Young Jin Kim,Leena Kinnunen,Norman Klopp,Augustine Kong,Eeva Korpi-Hyövälti,Sudhir Kowlessur,Peter Kraft,Jasmina Kravic,Malene M. Kristensen,S. Krithika,Ashok Kumar,Jesús Kumate,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Vasiliki Lagou,Timo A. Lakka,Claudia Langenberg,Cordelia Langford,Robert W. Lawrence,Karin Leander,Jen Mai Lee,Nanette R. Lee,Man Li,Xinzhong Li,Yun Li,Junbin Liang,Samuel Liju,Wei-Yen Lim,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Eero Lindholm,Ching-Ti Liu,Jianjun Liu,Stéphane Lobbens,Jirong Long,Ruth J. F. Loos,Ruth J. F. Loos,Wei Lu,Jian'an Luan,Valeriya Lyssenko,Ronald C. WMa,Shiro Maeda,Reedik Mägi,Satu Männistö,David R. Matthews,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Julia Meyer,Ghazala Mirza,Evelin Mihailov,Susanne Moebus,Viswanathan Mohan,Viswanathan Mohan,Karen L. Mohlke,Andrew D. Morris,Thomas WMühleisen,Martina Müller-Nurasyid,Martina Müller-Nurasyid,Bill Musk,Bill Musk,Jiro Nakamura,Eitaro Nakashima,Pau Navarro,Peng Keat Ng,Alexandra C. Nica,Peter M. Nilsson,Inger Njølstad,Markus M. Nöthen,Keizo Ohnaka,Twee Hee Ong,Katharine R. Owen,Colin N. A. Palmer,James S. Pankow,Kyong Soo Park,Melissa Parkin,Sonali Pechlivanis,Nancy L. Pedersen,Leena Peltonen,John R. B. Perry,John R. B. Perry,Annette Peters,Janani Pinidiyapathirage,Carl G. P. Platou,Simon C. Potter,Jackie F. Price,Lu Qi,Venkatesan Radha,Loukianos S. Rallidis,Asif Rasheed,Wolfgang Rathmann,Rainer Rauramaa,Soumya Raychaudhuri,N. William Rayner,Simon D. Rees,Simon D. Rees,Emil Rehnberg,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Neil Robertson,Michael Roden,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Igor Rudan,Denis Rybin,Timo Saaristo,Veikko Salomaa,Juha Saltevo,Maria Samuel,Dharambir KSanghera,Jouko Saramies,James Scott,Laura J. Scott,Robert A. Scott,Ayellet V. Segrè,Ayellet V. Segrè,Joban Sehmi,Joban Sehmi,Bengt Sennblad,Nabi Shah,Sonia Shah,A. Samad Shera,Xiao-Ou Shu,Alan R. Shuldiner,Gunnar Sigurosson,Eric J.G. Sijbrands,Angela Silveira,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Kerrin S. Small,Wing-Yee So,Alena Stančáková,Kari Stefansson,Kari Stefansson,Gerald Steinbach,Valgerdur Steinthorsdottir,Kathleen Stirrups,Rona J. Strawbridge,Heather M. Stringham,Qi Sun,Chen Suo,Ann-Christine Syvänen,Ryoichi Takayanagi,Fumihiko Takeuchi,Wan Ting Tay,Tanya M. Teslovich,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Emmi Tikkanen,Emmi Tikkanen,Joseph Trakalo,Elena Tremoli,Mieke D. Trip,Fuu Jen Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Adan Valladares-Salgado,Sailaja Vedantam,Sailaja Vedantam,Fabrizio Veglia,Benjamin F. Voight,Benjamin F. Voight,Congrong Wang,Nicholas J. Wareham,Roman Wennauer,Ananda R. Wickremasinghe,Tom Wilsgaard,James F. Wilson,S Wiltshire,Wendy Winckler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Andrew R. Wood,Jer-Yuarn Wu,Jer-Yuarn Wu,Ying Wu,Ken Yamamoto,Toshimasa Yamauchi,Mingyu Yang,Loic Yengo,Mitsuhiro Yokota,Robin Young,Delilah Zabaneh,Fan Zhang,Rong Zhang,Wei Zheng,Paul Zimmet,David Altshuler,David Altshuler,Donald W. Bowden,Donald W. Bowden,Yoon Shin Cho,Nancy J. Cox,Miguel Cruz,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Michael Boehnke,Esteban J. Parra,John C. Chambers,John C. Chambers,John C. Chambers,E. Shyong Tai,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris +395 more
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Yoon Shin Cho,Chien Hsiun Chen,Chien Hsiun Chen,Cheng Hu,Jirong Long,Rick Twee-Hee Ong,Xueling Sim,Fumihiko Takeuchi,Ying Wu,Min Jin Go,Toshimasa Yamauchi,Yi-Cheng Chang,Soo Heon Kwak,Ronald C.W. Ma,Ken Yamamoto,Linda S. Adair,Tin Aung,Qiuyin Cai,Li Ching Chang,Yuan-Tsong Chen,Yu-Tang Gao,Frank B. Hu,Hyung Lae Kim,Sangsoo Kim,Young-Jin Kim,Jeannette Lee,Nanette R. Lee,Yun Li,Jianjun Liu,Wei Lu,Jiro Nakamura,Eitaro Nakashima,Daniel P.K. Ng,Wan Ting Tay,Fuu Jen Tsai,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Mitsuhiro Yokota,Wei Zheng,Rong Zhang,Congrong Wang,Wing-Yee So,Keizo Ohnaka,Hiroshi Ikegami,Hara Kazuo,Young Min Cho,Nam H. Cho,Tien-Jyun Chang,Yuqian Bao,Åsa K. Hedman,Andrew P. Morris,Mark I. McCarthy,Ryoichi Takayanagi,Kyong Soo Park,Weiping Jia,Lee-Ming Chuang,Juliana C.N. Chan,Shiro Maeda,Takashi Kadowaki,Jong-Young Lee,Jer-Yuarn Wu,Jer-Yuarn Wu,Yik Ying Teo,Yik Ying Teo,E. Shyong Tai,Xiao-Ou Shu,Karen L. Mohlke,Norihiro Kato,Bok Ghee Han,Mark Seielstad,Mark Seielstad,Mark Seielstad +72 more
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Journal ArticleDOI
Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
TL;DR: Troglitazone treatment induces improvement in both glucose metabolism and blood pressure control in essential hypertensive patients with diabetes mellitus, suggesting that insulin resistance or plasma insulin level plays a role in the pathogenesis of essential hypertension.
Journal ArticleDOI
Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
Fumihiko Takeuchi,Masakuni Serizawa,Ken Yamamoto,Tomomi Fujisawa,Eitaro Nakashima,Keizo Ohnaka,Hiroshi Ikegami,Takao Sugiyama,Tomohiro Katsuya,Makoto Miyagishi,Naoki Nakashima,Hajime Nawata,Jiro Nakamura,Suminori Kono,Ryoichi Takayanagi,Norihiro Kato +15 more
TL;DR: The strength of association was more prominent in the Japanese population than in Europeans for more than half of the confirmed type 2 diabetes loci and significant associations were replicated in five other candidate loci.