Hiroshi Kida

TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.

TL;DR: A structural basis for the hypothesis that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics is demonstrated.

TL;DR: It is shown, by transmission electron microscopy of serially sectioned virions, that theRNPs of influenza A virus are organized in a distinct pattern (seven segments of different lengths surrounding a central segment), arguing against random incorporation of RNPs into virions and supporting instead a model in which each segment contains specific incorporation signals that enable the RNPs to be recruited and packaged as a complete set.

TL;DR: Assessment of growth potential of 42 strains of influenza virus in pigs indicates that avian influenza viruses with or without non-human-type HAs can be transmitted to pigs, thus raising the possibility of introduction of their genes into humans.

TL;DR: The robust replicative ability in mice, ferrets and nonhuman primates and the limited transmissibility in ferrets of Anhui/1 suggest that A(H7N9) viruses have pandemic potential.