H
Hiroshi Mikami
Researcher at Osaka University
Publications - 211
Citations - 4682
Hiroshi Mikami is an academic researcher from Osaka University. The author has contributed to research in topics: Blood pressure & Angiotensin II. The author has an hindex of 36, co-authored 207 publications receiving 4585 citations.
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Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
TL;DR: Troglitazone treatment induces improvement in both glucose metabolism and blood pressure control in essential hypertensive patients with diabetes mellitus, suggesting that insulin resistance or plasma insulin level plays a role in the pathogenesis of essential hypertension.
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Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia.
Hiromi Rakugi,Yoshikatsu Tabuchi,Mitsuaki Nakamaru,Masahiro Nagano,Koichi Higashimori,Hiroshi Mikami,Ogihara T,Nobuhiro Suzuki +7 more
TL;DR: It is suggested that endothelin contributes to endothelium-dependent vasoconstriction by hypoxia in mesenteric artery and may play an important role in the local peripheral vascular tone.
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Sympathetic Nerve Hyperactivity Precedes Hyperinsulinemia and Blood Pressure Elevation in a Young, Nonobese Japanese Population
TL;DR: It is demonstrated that sympathetic nerve hyperactivity appears to precede hyperinsulinemia and resultant BP elevation in a young, nonobese Japanese population.
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The Seasonal Variation of Blood Pressure in Patients with Essential Hypertension
Takeshi Hata,Toshio Ogihara,Anna Maruyama,Hiroshi Mikami,Mitsuaki Nakamaru,Toru Naka,Yuichi Kumahara,Charles A. Nugent +7 more
TL;DR: The blood pressure of patients with essential hypertension has a seasonal variation with higher pressures in the winter than in the summer, and an increased load of sodium presented to the kidney for excretion may be contributing factors in the rise in blood pressure in winter.
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Impaired endothelial function with essential hypertension assessed by ultrasonography.
Kaeko Iiyama,Masahiro Nagano,Yoshikage Yo,Noriko Nagano,Kei Kamide,Jitsuo Higaki,Hiroshi Mikami,Toshio Ogihara +7 more
TL;DR: The results suggest that endothelial dysfunction exists in patients with hypertension and precedes overt atherosclerotic disease, and isosorbide dinitrate-induced changes were similar.