Hiroshi Yamamoto

TL;DR: Clonal analyses show that PDGFRα+ cells also differentiate into collagen type-I-producing cells, indicating that mesenchymal progenitors are the main origin of not only fat accumulation but also fibrosis in skeletal muscle.

TL;DR: It is revealed that 100–200 clusters, filled with closely packed lymphocytes, can be found throughout the length of the antimesenteric wall of the mouse small intestine, which indicates that ILF, PP, and CP constitute three distinct organized gut-associated lymphoid tissues that reside in the lamina propria of the mice small intestine.

TL;DR: Gene set enrichment analysis revealed that quiescent satellite cells preferentially express the genes involved in cell‐cell adhesion, regulation of cell growth, formation of extracellular matrix, copper and iron homeostasis, and lipid transportation, and calcitonin receptor was exclusively expressed in dormant satellite cells but not in activated satellite cells.

TL;DR: The results indicate that macrophages directly affect satellite cell proliferation and that a macrophage deficiency severely impairs skeletal muscle regeneration and causes fibrosis.

TL;DR: The results suggest that SM/C-2.6 identifies and enriches quiescent satellite cells from adult mouse muscle, and that the antibody will be useful as a powerful tool for the characterization of cellular and molecular mechanisms of satellite cell activation and proliferation.