H
Hiroyuki Iwahana
Researcher at University of Tokushima
Publications - 64
Citations - 6547
Hiroyuki Iwahana is an academic researcher from University of Tokushima. The author has contributed to research in topics: Gene & Complementary DNA. The author has an hindex of 26, co-authored 64 publications receiving 6409 citations.
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Journal ArticleDOI
Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
TL;DR: The mobility shift analysis of single-stranded DNAs on neutral polyacrylamide gel electrophoresis to detect DNA polymorphisms was developed and SSCPs were found to be allelic variants of true Mendelian traits, and therefore they should be useful genetic markers.
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Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation.
Katsuhisa Oshikawa,Kenji Kuroiwa,Kenji Tago,Hiroyuki Iwahana,Ken Yanagisawa,Shoji Ohno,Shin-ichi Tominaga,Yukihiko Sugiyama +7 more
TL;DR: The results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma.
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Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells
Hiroyuki Iwahana,Ken Yanagisawa,Akiko Ito-Kosaka,Kenji Kuroiwa,Kenji Tago,Norio Komatsu,Rumi Katashima,Mitsuo Itakura,Shin-ichi Tominaga +8 more
TL;DR: It is demonstrated that the human ST2 gene has two alternative promoters followed by distinct noncoding first exons, which are located more than 8 kb apart and are spliced to the common exon 2 containing the translation initiation site.
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Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice.
Maki Moritani,Katsuhiko Yoshimoto,Fumi Tashiro,Chikara Hashimoto,Jun-ichi Miyazaki,Setsuko,Eiji Kudo,Hiroyuki Iwahana,Yoshio Hayashi,Toshiaki Sano,Mitsuo Itakura +10 more
TL;DR: Transgenic paracrine expression of IL-10 in situ in the NOD genetic background enhances autoimmune insulitis and diabetes in their onset and severity, ignoring gender difference.
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Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes.
Maki Moritani,Katsuhiko Yoshimoto,Maki Kondo,Hiroyuki Iwahana,Takashi Yamaoka,Toshiaki Sano,N Nakano,Hitoshi Kikutani,Mitsuo Itakura +8 more
TL;DR: The suppression of diabetes through decreasing IFN-gamma mRNA by the tissue-specific delivery of IL-10 to pancreatic islets with IL- 10-transduced Th1 cells affords the starting basis to develop the gene therapy for autoimmune diabetes.