H
Hiroyuki Koyama
Researcher at University of Tokyo
Publications - 85
Citations - 5829
Hiroyuki Koyama is an academic researcher from University of Tokyo. The author has contributed to research in topics: Basic fibroblast growth factor & Micelle. The author has an hindex of 33, co-authored 85 publications receiving 5503 citations. Previous affiliations of Hiroyuki Koyama include Saitama Medical University & University of Washington.
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Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Younsoo Bae,Nobuhiro Nishiyama,Shigeto Fukushima,Hiroyuki Koyama,Matsumura Yasuhiro,Kazunori Kataoka +5 more
TL;DR: In vitro and in vivo studies show that the micelles have the characteristic properties, such as an intracellular pH-triggered drug release capability, tumor-infiltrating permeability, and effective antitumor activity with extremely low toxicity.
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PEG-Detachable Polyplex Micelles Based on Disulfide-Linked Block Catiomers as Bioresponsive Nonviral Gene Vectors
Seiji Takae,Kanjiro Miyata,Makoto Oba,Takehiko Ishii,Nobuhiro Nishiyama,Keiji Itaka,Yuichi Yamasaki,Hiroyuki Koyama,Kazunori Kataoka +8 more
TL;DR: Findings suggest that the PEG-SS-P[Asp(DET)] micelle may have promising potential as a nonviral gene vector exerting high transfection with regulated timing and minimal cytotoxicity.
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Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.
Kanjiro Miyata,Yoshinori Kakizawa,Nobuhiro Nishiyama,Atsushi Harada,Yuichi Yamasaki,Hiroyuki Koyama,Kazunori Kataoka +6 more
TL;DR: The balance between the densities of the cationic charge and disulfide cross-linking in the thiolated polyplex played a crucial role in the delivery and controlled release of entrapped pDNA into the microenvironment of intracellular compartment to achieve the high transfection efficiency.
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Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier
Yutaka Miura,Tomoya Takenaka,Kazuko Toh,Shourong Wu,Hiroshi Nishihara,Mitsunobu R. Kano,Yasushi Ino,Takahiro Nomoto,Yu Matsumoto,Hiroyuki Koyama,Horacio Cabral,Nobuhiro Nishiyama,Kazunori Kataoka +12 more
TL;DR: It is likely that the selective and accelerated accumulation of cRGD/m into tumors occurred via an active internalization pathway, possibly transcytosis, thereby producing significant antitumor effects in an orthotopic mouse model of U87MG human glioblastoma.
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Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer
Nobuhiro Nishiyama,Aya Iriyama,Woo Dong Jang,Kanjiro Miyata,Keiji Itaka,Yuji Inoue,Hidenori Takahashi,Yasuo Yanagi,Yasuhiro Tamaki,Hiroyuki Koyama,Kazunori Kataoka +10 more
TL;DR: This work demonstrates a new biomedical application for dendrimers, and the first success in the photochemical-internalization-mediated gene delivery in vivo, in which these two components are assembled into one structure.