H
Hiroyuki Tomiyama
Researcher at Juntendo University
Publications - 58
Citations - 4795
Hiroyuki Tomiyama is an academic researcher from Juntendo University. The author has contributed to research in topics: Parkinsonism & Parkin. The author has an hindex of 30, co-authored 58 publications receiving 4347 citations. Previous affiliations of Hiroyuki Tomiyama include University of Ioannina.
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Journal ArticleDOI
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Yuko Nakabayashi,Yuko Nakabayashi,Ikuko Mizuta,Ikuko Mizuta,Yushi Hirota,Yushi Hirota,Chiyomi Ito,Chiyomi Ito,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Masahiko Watanabe,Atsushi Takeda,Hiroyuki Tomiyama,Kenji Nakashima,Kazuko Hasegawa,Fumiya Obata,Takeo Yoshikawa,Hideshi Kawakami,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda,Tatsushi Toda +26 more
TL;DR: The results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.
Journal ArticleDOI
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Owen A. Ross,Alexandra I. Soto-Ortolaza,Michael G. Heckman,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Christine Van Broeckhoven,Christine Van Broeckhoven,Jonathan Carr,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Alexis Elbaz,Carlo Ferrarese,Alessandro Ferraris,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,John P. A. Ioannidis,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Matthew J. Farrer,Matthew J. Farrer +70 more
TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.
Journal ArticleDOI
Clinical heterogeneity of α‐synuclein gene duplication in Parkinson's disease
Kenya Nishioka,Shin Hayashi,Matthew J. Farrer,Andrew B. Singleton,Hiroyo Yoshino,Hisamasa Imai,Toshiaki Kitami,Kenichi Sato,Ryu Kuroda,Hiroyuki Tomiyama,Koichi Mizoguchi,Miho Murata,Tatsushi Toda,Issei Imoto,Johji Inazawa,Yoshikuni Mizuno,Nobutaka Hattori +16 more
TL;DR: The objective of this study was to assess the frequency of SNCA multiplications among autosomal dominant hereditary Parkinson's disease (ADPD) patients.
Journal ArticleDOI
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
Manabu Funayama,Kenji Ohe,Kenji Ohe,Taku Amo,Norihiko Furuya,Junji Yamaguchi,Shinji Saiki,Yuanzhe Li,Kotaro Ogaki,Maya Ando,Hiroyo Yoshino,Hiroyuki Tomiyama,Kenya Nishioka,Kazuko Hasegawa,Hidemoto Saiki,Wataru Satake,Kaoru Mogushi,Ryogen Sasaki,Yasumasa Kokubo,Shigeki Kuzuhara,Tatsushi Toda,Yoshikuni Mizuno,Yasuo Uchiyama,Kinji Ohno,Nobutaka Hattori +24 more
TL;DR: CHCHD2 mutations are associated with, and might be a cause of, autosomal dominant Parkinson's disease, and further functional studies are needed to understand how mutant CHCHD 2 might play a part in the pathophysiology of Parkinson's Disease.
Journal ArticleDOI
Novel PINK1 mutations in early-onset parkinsonism.
Yasuko Hatano,Yuanzhe Li,Kenichi Sato,Shuichi Asakawa,Yasuhiro Yamamura,Hiroyuki Tomiyama,Hiroyo Yoshino,Masato Asahina,Susumu Kobayashi,Sharon Hassin-Baer,Chin-Song Lu,Arlene R. Ng,Raymond L. Rosales,Nobuyoshi Shimizu,Tatsushi Toda,Yoshikuni Mizuno,Nobutaka Hattori +16 more
TL;DR: Mutation analysis in eight inbred families whose haplotypes link to the PARK6 region identified six pathogenic mutations in six unrelated families, suggesting that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.