H
Hiroyuki Yamamoto
Researcher at St. Marianna University School of Medicine
Publications - 422
Citations - 19772
Hiroyuki Yamamoto is an academic researcher from St. Marianna University School of Medicine. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 71, co-authored 357 publications receiving 18399 citations. Previous affiliations of Hiroyuki Yamamoto include Sanford-Burnham Institute for Medical Research & Osaka University.
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Journal ArticleDOI
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Nicholas Rampino,Hiroyuki Yamamoto,Yurij Ionov,Yan Li,Hisako Sawai,John C. Reed,Manuel Perucho +6 more
TL;DR: The results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for coloreCTal carcinogenesis.
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Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis.
TL;DR: It is proposed that these matrilysin-mediated pathways provide the necessary and logical mechanisms to promote cancer progression.
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Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
Tae Matsumura,K. Sugimachi,Hisae Iinuma,Yukiko Takahashi,Junji Kurashige,Genta Sawada,Masami Ueda,R Uchi,Hiroki Ueo,Yuki Takano,Yoshiaki Shinden,Hidetoshi Eguchi,Hiroyuki Yamamoto,Yuichiro Doki,Masaki Mori,Takahiro Ochiya,Koshi Mimori +16 more
TL;DR: Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients and showed poorer prognoses than the low expression group.
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Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.
Kohzoh Imai,Hiroyuki Yamamoto +1 more
TL;DR: DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome, and the diagnosis of MSI-H in cancers is considered to be of increasing relevance.
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A DNA methylation fingerprint of 1628 human samples
Augustin F. Fernandez,Yassen Assenov,José I. Martín-Subero,Balázs Bálint,Reiner Siebert,Hiroaki Taniguchi,Hiroyuki Yamamoto,Manuel Hidalgo,Manuel Hidalgo,Aik Choon Tan,Oliver Galm,Isidre Ferrer,Montse Sanchez-Cespedes,Alberto Villanueva,Javier Carmona,Jose V. Sanchez-Mut,María Berdasco,Victor Moreno,Gabriel Capellá,David Monk,Esteban Ballestar,Santiago Ropero,Ramon Martinez,Marta Sanchez-Carbayo,Felipe Prosper,Xabier Agirre,Mario F. Fraga,Mario F. Fraga,Osvaldo Graña,Luis A. Pérez-Jurado,Jaume Mora,Susana Puig,Jaime Prat,Lina Badimon,Annibale Alessandro Puca,Stephen J. Meltzer,Thomas Lengauer,John Bridgewater,Christoph Bock,Manel Esteller +39 more
TL;DR: The DNA methylation patterns identified across the largest spectrum of samples, tissues, and diseases reported to date constitute a baseline for developing higher-resolutionDNA methylation maps and provide important clues concerning the contribution of CpG methylation to tissue identity and its changes in the most prevalent human diseases.