H
Ho Leung Ng
Researcher at Kansas State University
Publications - 53
Citations - 3971
Ho Leung Ng is an academic researcher from Kansas State University. The author has contributed to research in topics: Allosteric regulation & Binding site. The author has an hindex of 20, co-authored 47 publications receiving 3617 citations. Previous affiliations of Ho Leung Ng include University of Hawaii at Manoa & University of Hawaii.
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Journal ArticleDOI
Detecting Protein Function and Protein-Protein Interactions from Genome Sequences
Edward M. Marcotte,Matteo Pellegrini,Ho Leung Ng,Danny W. Rice,Todd O. Yeates,David Eisenberg +5 more
TL;DR: Searching sequences from many genomes revealed 6809 putative protein-protein interactions in Escherichia coli and 45,502 in yeast, and many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions.
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Saccharomyces cerevisiae septins: Supramolecular organization of heterooligomers and the mechanism of filament assembly
Aurélie Bertin,Michael A. McMurray,Patricia Grob,Sang-Shin Park,Galo Garcia,Insiyyah Patanwala,Ho Leung Ng,Tom Alber,Jeremy Thorner,Eva Nogales +9 more
TL;DR: Insight is provided into the molecular mechanisms underlying the function and regulation of cellular septin structures by confirming that the heterooligomer is octameric and revealed that the subunits are arrayed in a linear rod.
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Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals
Michael Z. Lin,Michael R. McKeown,Ho Leung Ng,Todd A. Aguilera,Nathan C. Shaner,Robert E. Campbell,Stephen R. Adams,Larry A. Gross,Wendy Ma,Tom Alber,Roger Y. Tsien +10 more
TL;DR: The evolution of far-red fluorescent proteins with peak excitation at 600 nm or above are reported, and the brightest one, Neptune, performs well in imaging deep tissues in living mice and reveals a novel mechanism for red-shifting involving the acquisition of a new hydrogen bond with the acylimine region of the chromophore.
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Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein
Jun Chu,Russell D. Haynes,Stéphane Y. Corbel,Pengpeng Li,Emilio Gonzalez-Gonzalez,John S Burg,Niloufar Ataie,Amy J. Lam,Paula J. Cranfill,Michelle A. Baird,Michael W. Davidson,Ho Leung Ng,Ho Leung Ng,K. Christopher Garcia,K. Christopher Garcia,Christopher H. Contag,Kang Shen,Kang Shen,Helen M. Blau,Michael Z. Lin +19 more
TL;DR: In this article, three new red-excitable monomeric fluorescent proteins obtained by structure-guided mutagenesis of mNeptune are described and used to visualize the differentiation of myoblasts into myocytes in living mice.
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A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo
Jun Chu,Younghee Oh,Alex Sens,Niloufar Ataie,Hod Dana,John J. Macklin,Tal Laviv,Erik S. Welf,Kevin M. Dean,Feijie Zhang,Benjamin Kim,Clement Tran Tang,Michelle Hu,Michelle A. Baird,Michael W. Davidson,Mark A. Kay,Reto Fiolka,Ryohei Yasuda,Douglas S. Kim,Ho Leung Ng,Ho Leung Ng,Michael Z. Lin +21 more
TL;DR: CyOFP1 is described, a bright, engineered, orange-red FP that is excitable by cyan light that enables single-excitation multiplexed imaging with GFP-based probes in single-Photon and two-photon microscopy, including time-lapse imaging in light-sheet systems.