H
Ho-Youn Kim
Researcher at Catholic University of Korea
Publications - 279
Citations - 12147
Ho-Youn Kim is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 57, co-authored 279 publications receiving 11053 citations. Previous affiliations of Ho-Youn Kim include The Catholic University of America & St Mary's Hospital.
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Journal ArticleDOI
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Sandra V. Navarra,Renato Guzman,Alberto E. Gallacher,Stephen B. Hall,Roger A. Levy,Renato E. Jimenez,Edmund K. Li,Mathew Thomas,Ho-Youn Kim,Manuel G. León,Coman Tanasescu,Eugeny L. Nasonov,Joung-Liang Lan,Lilia Pineda,Z. John Zhong,William W. Freimuth,Michelle A. Petri +16 more
TL;DR: The efficacy and safety of the fully human monoclonal antibody belimumab (BLyS-specific inhibitor) was assessed in patients with active systemic lupus erythematosus in a multicentre phase 3 study done in Latin America, Asia-Pacific, and eastern Europe.
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IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
Sue-Yun Hwang,Ju-Young Kim,Kyoung-Woon Kim,Mi-Kyung Park,Young-Mee Moon,Wan-Uk Kim,Ho-Youn Kim +6 more
TL;DR: IL-17 appears to be a stronger inducer of IL-6 and IL-8 than IL-15, and even exerted activation comparable to that ofIL-1β in RA FLS, and provide grounds for targeting IL-17-associated pathways in therapeutic modulation of arthritis inflammation.
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STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice
Mi La Cho,Jung Won Kang,Young Mee Moon,Hyo Jung Nam,Joo Yeon Jhun,Seong Beom Heo,Hyun Tak Jin,So Youn Min,Ji Hyeon Ju,Kyung Su Park,Young Gyu Cho,Chong Hyeon Yoon,Sung Hwan Park,Young Chul Sung,Ho-Youn Kim +14 more
TL;DR: The data suggest that IL-23 seems to be a central proinflammatory cytokine in the pathogenesis of this IL-1Ra−/− model of spontaneous arthritis, and its intracellular signaling pathway could be useful therapeutic targets in the treatment of autoimmune arthritis.
Journal ArticleDOI
The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.
TL;DR: It is found that TLRs are increased in OA cartilage lesions after treatment with TLR ligands led to phosphorylation of 3 MAPKs and activation of NF-kappaB.
Journal ArticleDOI
Correction: Corrigendum: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
Seung-Hoon Lee,Jin-Sil Park,Jae-Kyung Byun,Joo-Yeon Jhun,KyungAh Jung,Hyeon-Beom Seo,Young-Mee Moon,Ho-Youn Kim,Sung-Hwan Park,Mi-La Cho +9 more
TL;DR: This corrects the article DOI: 10.1038/srep34617 to indicate that the author of the paper is a doctor of medicine rather than a scientist, as previously reported.