H
Hollingworth R
Researcher at University of Birmingham
Publications - 1
Hollingworth R is an academic researcher from University of Birmingham. The author has contributed to research in topics: DNA damage & DNA Replication Fork. The author has co-authored 1 publications.
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A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling
Yuchen Yang,Jayaprakash D,Hollingworth R,Chen S,Jablonski Ae,Yanzhe Gao,Anand,Elizabeth Mutter-Rottmayer,An J,An J,Xiaolin Cheng,Xiaolin Cheng,Kenneth H. Pearce,Simon Blanchet,Amélie Fradet-Turcotte,Grant S. Stewart,Cyrus Vaziri +16 more
TL;DR: In this article, the E3 ligase RNF168 is recruited to DNA replication factories independent of the canonical DSB response pathway regulators and identify a degenerate PCNA-Interacting Peptide (DPIP) motif in the C-terminus of RNF 168 which mediates its binding to PCNA.