Holly R. Thomasson

TL;DR: The genotypes of the ADH2, ADH3, and ALDH2 loci of alcoholic and nonalcoholic Chinese men living in Taiwan are determined using leukocyte DNA amplified by the PCR and allele-specific oligonucleotides, suggesting that genetic variation in both ADH and AL DH, by modulating the rate of metabolism of ethanol and acetaldehyde, influences drinking behavior and the risk of developing alcoholism.

TL;DR: This chapter attempts to summarize the findings of studies from the last decade that examined the role of gender and sex hormone differences on ethanol metabolism in men and women and offers suggestions that may result in better cross-study comparisons and more consistent experimental results.

TL;DR: Alleles that encode the high activity forms of alcohol dehydrogenase, as well as the mutantALDH2*2 allele were less frequent in alcoholics than in controls, and the presence ofALDH 2*2 was associated with slower alcohol metabolism and the most intense flushing.

TL;DR: Compared ADH2, ADH3 and ALDH2 allele frequencies in patients with alcohol‐related cirrhosis and chronic pancreatitis are compared with 79 local healthy control subjects to study genetically determined differences in ethanol metabolism.

TL;DR: In this article, the genotypes at all three of these loci in Atayal natives of Taiwan were determined, and the frequencies of ADH2*2, ADH3*1, and ALDH2*1 alleles (0.91, 0.99, and 0.95, respectively) were significantly higher among the Atayan than among a predominantly Han Chinese population from Taiwan.