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Author

Hong Liu

Other affiliations: Shanghai University, Guangzhou University, University of Jinan  ...read more
Bio: Hong Liu is an academic researcher from Shandong University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 100, co-authored 1905 publications receiving 57561 citations. Previous affiliations of Hong Liu include Shanghai University & Guangzhou University.


Papers
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Journal ArticleDOI
24 Oct 2012-PLOS ONE
TL;DR: Investigation of whether the low-density lipoprotein receptor (LDLr) pathway is involved in the progression of VC in patients with end-stage renal disease (ESRD) during inflammation found it to be so, and inflammation-induced disruption of the LDLr pathway was significantly associated with enhanced BMP-2 and collagen I expression.
Abstract: Background: Chronic inflammation plays a crucial role in the progression of vascular calcification (VC). This study was designed to investigate whether the low-density lipoprotein receptor (LDLr) pathway is involved in the progression of VC in patients with end-stage renal disease (ESRD) during inflammation. Methods and Results: Twenty-eight ESRD patients were divided into control and inflamed groups according to plasma C-reactive protein (CRP) level. Surgically removed tissues from the radial arteries of patients receiving arteriovenostomy were used in the experiments. The expression of tumour necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein-1 (MCP-1) of the radial artery were increased in the inflamed group. Hematoxylin-eosin and alizarin red S staining revealed parallel increases in foam cell formation and calcium deposit formation in continuous cross-sections of radial arteries in the inflamed group compared to the control, which were closely correlated with increased LDLr, sterol regulatory element binding protein-2 (SREBP-2), bone morphogenetic proteins-2 (BMP-2), and collagen I protein expression, as shown by immunohistochemical and immunofluorescent staining. Confocal microscopy confirmed that inflammation enhanced the translocation of the SREBP cleavage-activating protein (SCAP)/SREBP-2 complex from the endoplasmic reticulum to the Golgi, thereby activating LDLr gene transcription. Inflammation increased alkaline phosphatase protein expression and reduced alpha-smooth muscle actin protein expression, contributing to the conversion of the vascular smooth muscle cells in calcified vessels from the fibroblastic to the osteogenic phenotype; osteogenic cells are the main cellular components involved in VC. Further analysis showed that the inflammation-induced disruption of the LDLr pathway was significantly associated with enhanced BMP-2 and collagen I expression. Conclusions: Inflammation accelerated the progression of VC in ESRD patients by disrupting the LDLr pathway, which may represent a novel mechanism involved in the progression of both VC and atherosclerosis.

30 citations

Journal ArticleDOI
TL;DR: In this article, the authors constructed puffed quaternary FexCoyNi1-x-yP nanoarrays as bifunctional electrodes for robust overall water splitting.
Abstract: Designing and constructing bifunctional electrocatalysts with high efficiency, high stability and low cost for overall water splitting to produce clean hydrogen fuel is attractive but highly challenging. Here we constructed puffed quaternary FexCoyNi1-x-yP nanoarrays as bifunctional electrodes for robust overall water splitting. The iron was used as the modulator to manipulate the electron density of NiCoP nanoarray, which could increase the positive charges of metal (Ni and Co) and P sites. The resultant electronic structure of FexCoyNi1-x-yP was supposed to balance the adsorption and desorption of H and accelerate the oxygen evolution reaction (OER) kinetics. Moreover, the morphological structure of FexCoyNi1-x-yP was modulated through the kinetically controlled alkaline etching by using the amphoteric features of initial FeCoNi hydroxide nanowires. The resultant puffed structure has rich porosity, cavity and defects, which benefit the exposure of more active sites and the transport of mass/ charge. As a result, the cell integrated with the puffed quaternary FexCoyNi1-x-yP nanoarrays as both the cathode and anode only requires the overpotentials of 25 and 230 mV for hydrogen evolution reaction (HER) and OER at the current density of 10 mA cm-2 in alkaline media and a cell voltage of 1.48 V to drive the overall water splitting. Moreover, the puffed FexCoyNi1-x-yP demonstrates remarkable durability for continuous electrolysis even at a large current density of 240 mA cm-2.

30 citations

Journal ArticleDOI
TL;DR: The details of AP-DSMC for multispecies Boltzmann equation are given, its AP property is shown, and it is verified through several numerical examples that the scheme can allow time step much larger than the mean free time, thus making it much more efficient for flows with possibly small Knudsen numbers than the classical DSMC.

29 citations

Journal ArticleDOI
Hongwei Liu1, Liu Bo1, Hong Liu1, Xiaolong Tong, Qin Liu 
TL;DR: This paper uses the Graphic Processing Unit (GPU) architecture to realize RTM and gets an order of magnitude higher speedup ratio compared to the traditional CPU architecture and analyzes the stability condition and dispersion relation of the finite difference (FD) method.
Abstract: Pre-stack reverse time migration (RTM) is a very useful tool for seismic imaging. But it has not been widely used because of the highly intensive computation cost, imaging noise and massy memory demand. In this paper, we present the implementation process of RTM and analyze the stability condition and dispersion relation of the finite difference (FD) method. For the problem of intensive computation cost, we use the Graphic Processing Unit (GPU) architecture to realize RTM and get an order of magnitude higher speedup ratio compared to the traditional CPU architecture. Compared to the one way wave equation migration methods, RTM does not have the imaging dip limit and the imaging effect is significantly improved. The tests on vertical fault and BP models prove this conclusion. The problems of imaging noise removal and massy memory demand will be discussed in other papers.

29 citations

Journal ArticleDOI
Qiangqiang Zhang1, Xin Li1, Chun Chang1, Zhifeng Wang1, Hong Liu1 
TL;DR: In this paper, an indoor testing system with a molten salt cavity receiver was developed to determine the thermal performance of a 100kWt molten salt receiver in an unsteady state condition.

29 citations


Cited by
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Journal ArticleDOI

[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: This Review describes how the tunable electronic structure of TMDs makes them attractive for a variety of applications, as well as electrically active materials in opto-electronics.
Abstract: Ultrathin two-dimensional nanosheets of layered transition metal dichalcogenides (TMDs) are fundamentally and technologically intriguing. In contrast to the graphene sheet, they are chemically versatile. Mono- or few-layered TMDs - obtained either through exfoliation of bulk materials or bottom-up syntheses - are direct-gap semiconductors whose bandgap energy, as well as carrier type (n- or p-type), varies between compounds depending on their composition, structure and dimensionality. In this Review, we describe how the tunable electronic structure of TMDs makes them attractive for a variety of applications. They have been investigated as chemically active electrocatalysts for hydrogen evolution and hydrosulfurization, as well as electrically active materials in opto-electronics. Their morphologies and properties are also useful for energy storage applications such as electrodes for Li-ion batteries and supercapacitors.

7,903 citations