Hong Liu

Bio: Hong Liu is an academic researcher from Shandong University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 100, co-authored 1905 publications receiving 57561 citations. Previous affiliations of Hong Liu include Shanghai University & Guangzhou University.

Direct synthesis and structure characterization of ultrafine CeO2 nanoparticles

Abstract: A new method to directly synthesize single-crystalline CeO2 nanoparticles has been developed. The advantages of the method are rapid synthesis, at normal atmosphere, 100% productive ratio and low cost, with a great potential for scale-up. X-ray diffraction (XRD) spectra showed unusual peak width versus particle size, compared with Scherrer equation predictions. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), electron diffraction and ultraviolet (UV) absorption were used to examine the particle size and microstructure to find out the cause. As a result, ultrafine particles with a size less than 6 nm were found to be self-assembled into a 'coherent interface', so that a large group of particles behave like a large single particle in XRD.

Efficient Charges Separation Using Advanced BiOI-Based Hollow Spheres Decorated with Palladium and Manganese Dioxide Nanoparticles

Abstract: Multishell hollow structures have attracted tremendous attention due to their outstanding properties for application on photocatalysis. In this work, we demonstrated a straightforward and general method to construct BiOI-based core-double shell hollow spheres for the first time. The core-double shell hollow spheres consist of Pd particles and MnOx loaded onto the inner and outer surfaces of BiOI hollow spheres, respectively (Pd/BiOI/MnOx), and utilized them as an advanced photocatalyst for photocatalytic oxidation of formaldehyde gases and methyl blue. The hollow spheres structure could provide a large specific surface area, exposing a large number of catalytic active sites. Additionally, the Pd particles and MnOx serve the function of separating the reduction and oxidation reactive sites. The unique morphology combined with enhanced light-absorption provided the Pd/BiOI/MnOx core-double shell hollow spheres with high efficiency for the photocatalytic oxidation of formaldehyde gases and methyl blue. In si...

Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer.

Abstract: Purpose: The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides and presented by class I MHC on the surface of tumor cells, we used alpha-fetoprotein (AFP), a specific liver cancer marker, as an example to determine whether peptide–MHC complexes can be targets for CAR T-cell therapy against solid tumors. Experimental Design: We generated a fully human chimeric antigen receptor, ET1402L1-CAR (AFP-CAR), with exquisite selectivity and specificity for the AFP158–166 peptide complexed with human leukocyte antigen (HLA)-A*02:01. Results: We report that T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01+/AFP+ while sparing cells from multiple tissue types that were negative for either expressed proteins. In vivo, intratumoral injection of AFP-CAR T cells significantly regressed both Hep G2 and AFP158-expressing SK-HEP-1 tumors in SCID-Beige mice (n = 8 for each). Moreover, intravenous administration of AFP-CAR T cells in Hep G2 tumor-bearing NSG mice lead to rapid and profound tumor growth inhibition (n = 6). Finally, in an established intraperitoneal liver cancer xenograft model, AFP-CAR T cells showed robust antitumor activity (n = 6). Conclusions: This study demonstrates that CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. Our approach expands the spectrum of antigens available for redirected T-cell therapy against solid malignancies and offers a promising new avenue for liver cancer immunotherapy. Clin Cancer Res; 23(2); 478–88. ©2016 AACR.

Cerium-based hybrid nanorods for synergetic photo-thermocatalytic degradation of organic pollutants

Abstract: In this work, phase boundary engineered cerium oxide–cerium nitride (CeO2/CeN) is synthesized and used as a high performance photocatalyst for photo-thermocatalytic degradation of organic pollutants in wastewater. A CeO2/CeN composite is obtained through simply annealing CeO2 nanowires under an ammonia atmosphere. Both theoretical and experimental analyses are used to study the interfacial interaction between CeO2 and CeN crystallites. Benefiting from the interface engineering, the as-prepared CeO2/CeN composite exhibits higher photo-thermocatalytic performance than pristine CeO2 for the removal of organic pollutants. Electron spin resonance (ESR) spectroscopy and liquid chromatography tandem mass spectrometry analysis of intermediates and products are used to further confirm the synergetic effect and degradation mechanism of the photo-thermocatalysis reactions. The results of this work suggest that the synergetic effect of the photo-thermal reaction can be considered as one of the most efficient strategies for environmental pollution remediation.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

The chemistry of two-dimensional layered transition metal dichalcogenide nanosheets

Abstract: Ultrathin two-dimensional nanosheets of layered transition metal dichalcogenides (TMDs) are fundamentally and technologically intriguing. In contrast to the graphene sheet, they are chemically versatile. Mono- or few-layered TMDs - obtained either through exfoliation of bulk materials or bottom-up syntheses - are direct-gap semiconductors whose bandgap energy, as well as carrier type (n- or p-type), varies between compounds depending on their composition, structure and dimensionality. In this Review, we describe how the tunable electronic structure of TMDs makes them attractive for a variety of applications. They have been investigated as chemically active electrocatalysts for hydrogen evolution and hydrosulfurization, as well as electrically active materials in opto-electronics. Their morphologies and properties are also useful for energy storage applications such as electrodes for Li-ion batteries and supercapacitors.