Hong Liu

Bio: Hong Liu is an academic researcher from Shandong University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 100, co-authored 1905 publications receiving 57561 citations. Previous affiliations of Hong Liu include Shanghai University & Guangzhou University.

Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase.

Abstract: Purpose: Recent epidemiological and clinical studies have suggested the benefit of aspirin for patients with cancer, which inspired increasing efforts to demonstrate the anticancer ability of aspirin and reveal the molecular mechanisms behind. Nevertheless, the anticancer activity and related mechanisms of aspirin remain largely unknown. This study aimed to confirm this observation, and more importantly, to investigate the potential target contributed to the anticancer of aspirin.Experimental Design: A homogeneous time-resolved fluorescence (HTRF) assay was used to examine the impact of aspirin on heparanase. Streptavidin pull-down, surface plasmon resonance (SPR) assay, and molecular docking were performed to identify heparanase as an aspirin-binding protein. Transwell, rat aortic rings, and chicken chorioallantoic membrane model were used to evaluate the antimetastasis and anti-angiogenesis effects of aspirin, and these phenotypes were tested in a B16F10 metastatic model, MDA-MB-231 metastatic model, and MDA-MB-435 xenograft model.Results: This study identified heparanase, an oncogenic extracellular matrix enzyme involved in cancer metastasis and angiogenesis, as a potential target of aspirin. We had discovered that aspirin directly binds to Glu225 region of heparanase and inhibits the enzymatic activity. Aspirin impeded tumor metastasis, angiogenesis, and growth in heparanase-dependent manner.Conclusions: In summary, this study has illustrated heparanase as a target of aspirin for the first time. It provides insights for a better understanding of the mechanisms of aspirin in anticancer effects, and offers a direction for the development of small-molecule inhibitors of heparanase. Clin Cancer Res; 23(20); 6267-78. ©2017 AACR.

Chemical kinetic resolution of unprotected β-substituted β-amino acids using recyclable chiral ligands.

Abstract: The first chemical method for resolution of N,C-unprotected β-amino acids was developed through enantioselective formation and disassembly of nickel(II) complexes under operationally convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled along with isolation of the target β-substituted-β-amino acids in good yields and excellent enantioselectivity. The method features a broad synthetic generality including β-aryl, β-heteroaryl, and β-alkyl-derived β-amino acids. The procedure is easily scaled up, and was used for the synthetically and economically advanced preparation of the anti-diabetic drug sitagliptin.

Surface charge regulation of osteogenic differentiation of mesenchymal stem cell on polarized ferroelectric crystal substrate

Abstract: Polarized ferroelectric crystal lithium niobate wafers with different cuts are selected to offer differently charged surfaces By induction of the mesenchymal stem cells differentiation into osteoblasts on different charged surfaces, the specific osteogenic-associated markers are assessed and the results illustrate that the positively charged wafer surface enhances rBMMSCs osteogenic differentiation

Fe3O4–MWCNT magnetic nanocomposites as efficient peroxidase mimic catalysts in a Fenton-like reaction for water purification without pH limitation

Abstract: The Fenton-based reaction is powerful enough to decompose refractory organic pollutants, but it is limited by having a low pH range and it is necessary to have a secondary disposal of the iron sludge. This study demonstrates that Fe3O4–multi-walled carbon nanotube (Fe3O4–MWCNT) magnetic hybrids can be used as an efficient peroxidase mimic catalyst that could overcome such pH limitations in a Fenton-like reaction and could be reused after a simple magnetic separation. The Fe3O4–MWCNT hybrid was prepared using a simple one-pot strategy via in situ growth of Fe3O4 magnetic nanoparticles onto the surface of the MWCNTs. In this process, MWCNTs act as an excellent dispersant, which ensures that the Fe3O4 is well dispersed. The Fe3O4–MWCNT hybrid was characterized by X-ray diffractometry, Fourier transform infrared spectrometer, thermogravimetric analysis and vibrating sample magnetometry, which indicated that the Fe3O4 nanoparticles were successfully deposited on to the surface of MWCNTs. Furthermore, it was revealed that the Fe3O4–MWCNTs could catalyze H2O2 decomposition by acting as a peroxidase mimic catalyst. Then heterogenous Fenton-like reactions were performed using the Fe3O4–MWCNT nanocomposites as a catalyst to degrade methylene blue (10.0 mg L−1; MB) in aqueous solution. The results showed that MB could be efficiently removed in a broad pH range of 1.0–10.0, with a degradation efficiency of 88.13% to 98.68% in two hours, and a highest total organic carbon removal efficiency of 35.6% in 12 hours. Furthermore, the magnetic nanocomposites exhibited an enhanced removal efficiency for MB compared with the Fe3O4 magnetic nanocomparticles and MWCNTs used individually. In addition, Fe3O4–MWCNT nanocomposites exhibited strong magnetism, and thereby could be easily separated from aqueous solution using an external magnetic field. Therefore, the as-prepared Fe3O4–MWCNT nanocomposites could be used as a promising and effective catalyst in Fenton-like reactions for the purification of MB polluted water in a wide pH range.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

The chemistry of two-dimensional layered transition metal dichalcogenide nanosheets

Abstract: Ultrathin two-dimensional nanosheets of layered transition metal dichalcogenides (TMDs) are fundamentally and technologically intriguing. In contrast to the graphene sheet, they are chemically versatile. Mono- or few-layered TMDs - obtained either through exfoliation of bulk materials or bottom-up syntheses - are direct-gap semiconductors whose bandgap energy, as well as carrier type (n- or p-type), varies between compounds depending on their composition, structure and dimensionality. In this Review, we describe how the tunable electronic structure of TMDs makes them attractive for a variety of applications. They have been investigated as chemically active electrocatalysts for hydrogen evolution and hydrosulfurization, as well as electrically active materials in opto-electronics. Their morphologies and properties are also useful for energy storage applications such as electrodes for Li-ion batteries and supercapacitors.