The mol­ecule of the title benzohydrazide derivative, C15H14N2O4, exists in a trans conformation with respect to the C=N double bond and is twisted, the dihedral angle between the two benzene rings being 24.17 (6)°. The meth­oxy group is almost co-planar with respect to the attached benzene ring [Cm—O—C—C (m = meth­yl) = −1.45 (17)°]. In the crystal, the mol­ecules are linked by N—H⋯O and O—H⋯O hydrogen bonds into sheets parallel to the bc plane. These sheets are further connected into a three-dimensional network by weak C—H⋯O and C—H⋯π inter­actions.

https://journals.iucr.org/e/issues/2011/10/00/hb6400/hb6400.pdf

(E)-4-Hy-droxy-N'-(3-hy-droxy-4-meth-oxy-benzyl-idene)benzohydrazide.

In the title compound, C16H16N2O3, the benzohydrazide group is not planar and the mol­ecule exists in a trans configuration with respect to the methyl­idene unit The dihedral angle between the two substituted benzene rings is 269 (2)° In the crystal structure, the mol­ecular packing is stabilized by intra­molecular O—H⋯N and inter­molecular N—H⋯O hydrogen bonds The inter­molecular hydrogen bonding forms chains parallel to the b axis

https://journals.iucr.org/e/issues/2009/04/00/bx2198/bx2198.pdf

(E)-N′-[1-(2-Hydroxy­phen­yl)ethyl­idene]-3-methoxy­benzohydrazide

The title benzohydrazide derivative, C17H18N2O5, exists in a trans conformation with respect to the C=N double bond. The dihedral angle between the benzene rings is 19.41 (5)°. The two meth­oxy groups at the meta positions of the trimeth­oxy­benzene group are almost coplanar with the ring [C—O—C—C = 1.62 (16) and 178.33 (10)°], whereas the third meth­oxy group, at the para position, is (+)-synclinal with the ring. In the crystal, mol­ecules are linked by N—H⋯O and bifurcated O—H⋯(N,O) hydrogen bonds, as well as weak C—H⋯O inter­actions, into sheets lying parallel to the ac plane. A C—H⋯π inter­action also occurs.

https://journals.iucr.org/e/issues/2012/03/00/is5059/is5059.pdf

(E)-4-Hy-droxy-N'-(3,4,5-trimeth-oxy-benzyl-idene)benzohydrazide.

− A new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography. The structure of the isolated compounds was identified by UV, IR NMR and MS. C. gigantea was scientifically reported for several medicinal properties viz. analgesic, antimicrobial and cytotoxic. In this screening work, anti-microbial activity of test compounds was found to be active against all organisms. Additionally, anti-inflammatory activity of the test groups has reduced the thickness of edema of the hind paw compared to the control group. Keywords−Calotropis gigantea white, anti-microbial activity, Anti-inflammatory activity, 4-methoxy-3-(methoxymethyl) phenol, (E)-N'-(5-bromo-2-methoxybenzylidene)-4-methoxy benzohydrazide

/pdf/anti-microbial-and-anti-inflammatory-activity-of-new-4-48wfmf0bho.pdf

Anti-microbial and Anti-inflammatory Activity of New 4-methoxy-3-(methoxymethyl) Phenol and (E)-N′-(5-bromo-2-methoxybenzylidene)-4-methoxy Benzohydrazide Isolated from Calotropis gigantean white

The hydrazone mol­ecule of the title compound, C15H13N3O4·CH4O, is nearly planar, with a dihedral angle between the two benzene rings of 1.2 (4)°. The mol­ecule exists in a trans configuration with respect to the central methyl­idene unit. In the crystal, the benzohydrazide and methanol mol­ecules are linked through inter­molecular O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds, forming chains along the a axis.

https://journals.iucr.org/e/issues/2010/12/00/rz2522/rz2522.pdf

(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate.

In the title compound, C16H15BrN2O3, the benzohydrazide group is not planar and the mol­ecule exists in a trans configuration with respect to the methyl­idene unit. The dihedral angle between the two substituted benzene rings is 75.6 (2)°. In the crystal structure, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds involving carbonyl and amine functionalities, to form chains parallel to the c cell axis.

/pdf/e-n-5-bromo-2-methoxy-benzyl-idene-4-methoxy-benzohydrazide-2uxwp4kvq7.pdf

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide.

In the title compound, C15H12ClN3O4, the benzohydrazide group is not planar and the mol­ecule exists in a trans configuration with respect to the methyl­idene unit. The dihedral angle between the two substituted benzene rings is 0.4 (3)°. In the crystal structure, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds, forming chains parallel to the c axis.

/pdf/e-n-2-chloro-5-nitro-benzyl-idene-4-methoxy-benzohydrazide-1c1zk9ccny.pdf

(E)-N'-(2-Chloro-5-nitro-benzyl-idene)-4-methoxy-benzohydrazide.

The mol­ecule of the title compound, C14H11N3O4, is approximately planar, the dihedral angle between the planes of the two substituted benzene rings being 2.54 (7)°. The mol­ecule exists in a trans configuration with respect to the central methyl­idene unit. In the crystal structure, mol­ecules are linked through inter­molecular O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds, forming layers parallel to (101). The O/N—H⋯O and C—H⋯O inter­actions form a pair of bifurcated acceptor bonds involving the cabon­yl/nitro O atom, generating an R21(6) motif.

https://journals.iucr.org/e/issues/2009/07/00/ci2812/ci2812.pdf

Hong-Yan Ban

Papers

(E)-N′-[1-(2-Hydroxyphenyl)ethylidene]-3-methoxybenzohydrazide

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide.

(E)-N'-(2-Chloro-5-nitro-benzyl-idene)-4-methoxy-benzohydrazide.

(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate.

(E)-4-Hydroxy-N′-(4-nitrobenzylidene)benzohydrazide

Hong-Yan Ban

Papers

(E)-N′-[1-(2-Hydroxy­phen­yl)ethyl­idene]-3-methoxy­benzohydrazide

(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide.

(E)-N'-(2-Chloro-5-nitro-benzyl-idene)-4-methoxy-benzohydrazide.

(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate.

(E)-4-Hydr­oxy-N′-(4-nitro­benzyl­idene)benzohydrazide

(E)-N′-[1-(2-Hydroxyphenyl)ethylidene]-3-methoxybenzohydrazide

(E)-4-Hydroxy-N′-(4-nitrobenzylidene)benzohydrazide