Hongjian Song

TL;DR: A new derivative, 14, with optimized physicochemical properties, obviously exhibited higher activities in vivo than Ribavirin and other derivatives; therefore, 14 can be used as a new lead structure for the development of anti-TMV drugs.

TL;DR: A protocol for direct visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using molecular oxygen as an oxidant at room temperature is reported.

TL;DR: This highly efficient, scalable reaction showed excellent deuterium incorporation, a broad substrate scope, and excellent functional group tolerance and selectivity and is therefore a practical method for late-stage modification of synthetic intermediates in medicinal chemistry and for generating libraries of deuterated compounds.

TL;DR: An efficient, practical photocatalytic deoxygenation/defluorination protocol for the synthesis of γ,γ-difluoroallylic ketones from commercially available aromatic carboxylic acids, triphenylphosphine, and α-trifluoromethyl alkenes is described.

TL;DR: Bioassays indicated that compounds containing α-chloromethyl-N-benzyl and compounds containing 4,5-dihydrooxazole showed high insecticidal activity against cotton bollworm, and a trivial change at 4-position of pyrazole ring would lead to great changes in properties and activities.