Author
Hongwei Jin
Bio: Hongwei Jin is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Nanomedicine. The author has an hindex of 2, co-authored 2 publications receiving 982 citations.
Topics: Nanomedicine
Papers
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TL;DR: It is shown that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls ofAlginate and improve electrical communication between adjacent cardiac cells.
Abstract: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues.
593 citations
01 Sep 2011
TL;DR: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues as discussed by the authors, which can improve the electrical communication among cells.
Abstract: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues.
482 citations
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TL;DR: A simple architecture for a flexible and highly sensitive strain sensor that enables the detection of pressure, shear and torsion and can be used to monitor signals ranging from human heartbeats to the impact of a bouncing water droplet on a superhydrophobic surface is presented.
Abstract: Flexible skin-attachable strain-gauge sensors are an essential component in the development of artificial systems that can mimic the complex characteristics of the human skin. In general, such sensors contain a number of circuits or complex layered matrix arrays. Here, we present a simple architecture for a flexible and highly sensitive strain sensor that enables the detection of pressure, shear and torsion. The device is based on two interlocked arrays of high-aspect-ratio Pt-coated polymeric nanofibres that are supported on thin polydimethylsiloxane layers. When different sensing stimuli are applied, the degree of interconnection and the electrical resistance of the sensor changes in a reversible, directional manner with specific, discernible strain-gauge factors. The sensor response is highly repeatable and reproducible up to 10,000 cycles with excellent on/off switching behaviour. We show that the sensor can be used to monitor signals ranging from human heartbeats to the impact of a bouncing water droplet on a superhydrophobic surface.
1,431 citations
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1,146 citations
TL;DR: Recent progress in electronic skin or e‐skin research is broadly reviewed, focusing on technologies needed in three main applications: skin‐attachable electronics, robotics, and prosthetics.
Abstract: Recent progress in electronic skin or e-skin research is broadly reviewed, focusing on technologies needed in three main applications: skin-attachable electronics, robotics, and prosthetics. First, since e-skin will be exposed to prolonged stresses of various kinds and needs to be conformally adhered to irregularly shaped surfaces, materials with intrinsic stretchability and self-healing properties are of great importance. Second, tactile sensing capability such as the detection of pressure, strain, slip, force vector, and temperature are important for health monitoring in skin attachable devices, and to enable object manipulation and detection of surrounding environment for robotics and prosthetics. For skin attachable devices, chemical and electrophysiological sensing and wireless signal communication are of high significance to fully gauge the state of health of users and to ensure user comfort. For robotics and prosthetics, large-area integration on 3D surfaces in a facile and scalable manner is critical. Furthermore, new signal processing strategies using neuromorphic devices are needed to efficiently process tactile information in a parallel and low power manner. For prosthetics, neural interfacing electrodes are of high importance. These topics are discussed, focusing on progress, current challenges, and future prospects.
881 citations
TL;DR: This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications and discusses synthesis and fabrication of nanoparticles within the hydrogel network.
Abstract: Hydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon-based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydrogel networks to obtain nanocomposites with superior properties and tailored functionality. Nanocomposite hydrogels can be engineered to possess superior physical, chemical, electrical, and biological properties. This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications. In particular, we discuss synthesis and fabrication of nanocomposite hydrogels, examine their current limitations and conclude with future directions in designing more advanced nanocomposite hydrogels for biomedical and biotechnological applications.
876 citations
TL;DR: Results indicate that the electrically conductive and nanofibrous networks formed by CNTs within a porous gelatin framework are the key characteristics of CNT-GelMA leading to improved cardiac cell adhesion, organization, and cell-cell coupling.
Abstract: We engineered functional cardiac patches by seeding neonatal rat cardiomyocytes onto carbon nanotube (CNT)-incorporated photo-cross-linkable gelatin methacrylate (GelMA) hydrogels. The resulting cardiac constructs showed excellent mechanical integrity and advanced electrophysiological functions. Specifically, myocardial tissues cultured on 50 μm thick CNT-GelMA showed 3 times higher spontaneous synchronous beating rates and 85% lower excitation threshold, compared to those cultured on pristine GelMA hydrogels. Our results indicate that the electrically conductive and nanofibrous networks formed by CNTs within a porous gelatin framework are the key characteristics of CNT-GelMA leading to improved cardiac cell adhesion, organization, and cell–cell coupling. Centimeter-scale patches were released from glass substrates to form 3D biohybrid actuators, which showed controllable linear cyclic contraction/extension, pumping, and swimming actuations. In addition, we demonstrate for the first time that cardiac tiss...
775 citations