Hoogenboom Hendricus R J M

TL;DR: In this paper, a member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbps members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof.

TL;DR: In this paper, the authors described methods for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species.

TL;DR: In this article, a method for inhibiting the human tumor necrosis factor (TNF) activity, including contact between the human TNF α and an antibody, is provided, wherein the antibody is the isolated human antibody dissociating from the humanTNF α at rate constants of K d below 1×10 -8 M and K off below 1x10 -3 s -1 or its antigen-binding portion, both of which are measured by surface plasmon resonance, and the antibody neutralizes the cytotoxicity of the human L929 assay at IC 50 below

TL;DR: In this article, the authors described methods for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species.

TL;DR: In this paper, recombinant human antibodies that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed, which are useful for detecting and inhibiting human TNFα activity.