Author
Horst Brandt
Bio: Horst Brandt is an academic researcher. The author has contributed to research in topics: Acrosome reaction & Capacitation. The author has an hindex of 1, co-authored 1 publications receiving 44 citations.
Topics: Acrosome reaction, Capacitation, Sperm, Population
Papers
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TL;DR: The combination of sperm responsiveness parameters applied here is a suitable tool for the evaluation of sperm function and improved the prediction level of multiple regression models for farrowing rate and litter size.
45 citations
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TL;DR: The discussion of the major aspects of ZAG from its gene structure to function and metabolism is discussed, which suggests that ZAG may have a role in the expression of the immune response.
Abstract: Zinc alpha 2-glycoprotein (ZAG) is a protein of interest because of its ability to play many important functions in the human body, including fertilization and lipid mobilization After the discovery of this molecule, during the last 5 decades, various studies have been documented on its structure and functions, but still, it is considered as a protein with an unknown function Its expression is regulated by glucocorticoids Due to its high sequence homology with lipid-mobilizing factor and high expression in cancer cachexia, it is considered as a novel adipokine On the other hand, structural organization and fold is similar to MHC class I antigen-presenting molecule; hence, ZAG may have a role in the expression of the immune response The function of ZAG under physiologic and cancerous conditions remains mysterious but is considered as a tumor biomarker for various carcinomas There are several unrelated functions that are attributed to ZAG, such as RNase activity, regulation of melanin production, hindering tumor proliferation, and transport of nephritic by-products This article deals with the discussion of the major aspects of ZAG from its gene structure to function and metabolism
207 citations
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TL;DR: Current and past data, correlating laboratory assay data with sperm fertility are presented in an effort to determine which types of assays are important to conduct and when to conduct them.
167 citations
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TL;DR: This work has developed a simple and cost-efficient flow cytometric approach for identifying non-sperm particles that can be carried out in parallel with functional assessments and is suitable for obtaining accurate sperm counts during routine semen evaluation.
111 citations
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TL;DR: Assessing both the conventional sperm quality parameters and the immunolabeling of three proteins involved in the physiology of the sperm cell suggest that analyzing these sperm kinematic parameters could be a useful tool for predicting the potential freezability of an ejaculate.
97 citations
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TL;DR: Improved techniques for evaluating semen characteristics directly related to the fertilization process, such as IVM-IVF assays, analysis of seminal plasma protein markers, and discriminatory tests of sperm motility and morphology are reviewed with the goal of identifying high-index boars whose fertility is sustained when low numbers of sperm are used for AI.
90 citations