H
Horst Kessler
Researcher at Technische Universität München
Publications - 880
Citations - 47014
Horst Kessler is an academic researcher from Technische Universität München. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Integrin. The author has an hindex of 101, co-authored 878 publications receiving 44392 citations. Previous affiliations of Horst Kessler include University of Arizona & Weizmann Institute of Science.
Papers
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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
TL;DR: The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.
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Activation of Integrin Function by Nanopatterned Adhesive Interfaces
Marco Arnold,Elisabetta Ada Cavalcanti-Adam,Roman Glass,Jacques Blümmel,Wolfgang Eck,Martin Kantlehner,Horst Kessler,Joachim P. Spatz +7 more
TL;DR: It is proposed that the range between 58-73 nm is a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells.
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Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands
Elisabetta Ada Cavalcanti-Adam,Tova Volberg,Alexandre Micoulet,Horst Kessler,Benjamin Geiger,Joachim P. Spatz +5 more
TL;DR: It is shown that cell-surface attachment is not sensitive to pattern density, whereas the formation of stable focal adhesions and persistent spreading is, and a critical RGD density is essential for the establishment of mature and stable integrin adhesion, which, in turn, induce efficient cell spreading and formation of focal adhesion dynamics.
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N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
Michael A. Dechantsreiter,Eckart Planker,Barbara Mathä,Elisabeth Lohof,Günter Hölzemann,Alfred Jonczyk,Simon Goodman,Horst Kessler +7 more
TL;DR: Cyclo(RGDf-N(Me)V-) (P5) was found to be even more active than L1 and is one of the most active and selective compounds in inhibiting vitronectin binding to the alpha(V)beta(3) integrin.
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Conformation and Biological Activity of Cyclic Peptides
TL;DR: In this paper, the authors proposed a model for peptide conformation analysis using NMR spectroscopic methods, including many recent advances, in relation to their ability to contribute to peptide conformational analysis.