Author
Hossein Najafzadehvarzi
Bio: Hossein Najafzadehvarzi is an academic researcher from Babol University of Medical Sciences. The author has contributed to research in topics: Medicine & Targeted drug delivery. The author has an hindex of 4, co-authored 11 publications receiving 63 citations.
Topics: Medicine, Targeted drug delivery, Andrology, Follicular fluid, Oocyte
Papers
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TL;DR: EA can be useful for protecting brain tissue against ACR-induced neurotoxicity through ameliorative effects on inflammatory indices and oxidative stress parameters, and histopathological observations of the brain are supported.
Abstract: Acrylamide (ACR) is an environmental contaminant and a well-known neurotoxin. Ellagic acid (EA), a natural plant polyphenol, has shown a variety of beneficial effects. The present study was designe...
51 citations
TL;DR: In this article, Carum copticum (05% and 1%) and lactic acid were examined for a period of 18 days and the results showed that TVC, PTC, pH, thiobarbituric acid reactive substances (TBARS), total volatile base nitrogen (TVN), and biogenic amines (histamine, cadaverine, and putrescine) values were significantly reduced.
Abstract: Common carp (Cyprinus carpio) samples treated with Carum copticum (05% and 1%) and lactic acid were examined for a period of 18 days Samples were analysed for their total viable count (TVC), psychrotrophic count (PTC), pH, thiobarbituric acid reactive substances (TBARS), total volatile base nitrogen (TVN) and biogenic amines (histamine, cadaverine, and putrescine) to evaluate their quality and safety The TVC, PTC, pH, and TVN values were significantly reduced (p
23 citations
TL;DR: In this paper, the capacity of an aptamer-based drug carrier to deliver Paclitaxel (PTX) to cancer cells was evaluated using different methods, including differential light scattering (DLS), infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), Thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM).
Abstract: Targeted drug delivery vehicles make it possible to deliver anti-cancer drugs to the cells or tissues of interest. Aptamers are peptide or oligonucleotide molecules that can serve as targeting elements of drug carriers. In the current study, we evaluated the capacity of an aptamer-based drug carrier to deliver Paclitaxel (PTX) to cancer cells. After being synthesized, SPIONs@PTX-SYL3C aptamer was characterized using different methods, including differential light scattering (DLS), infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), X-ray diffraction (XRD), Thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Encapsulation efficiency (EE) and loading efficiency (LE) were also evaluated. The carrier was applied on 4T1, MCF 7, and MCF-10A breast cell lines to evaluate its drug delivery potency and specificity. EE and LE were calculated to be 77.6% and 7.76%, respectively. MTT results revealed that aptameric SPIONs@PTX was more toxic than non-aptameric SPIONs@PTX. Flowcytometry analysis and DAPI staining confirmed that SPIONs@PTX-Aptamer had higher cell internalization rate when compared to non-targeted SPIONs@PTX. Our results indicate that aptamer-conjugated SPIONs@PTX has a good capacity in recognizing its target cells and inhibiting their growth and division.
13 citations
TL;DR: In this article, apigenin was isolated and purified from parsley leaves and to enhance its bioavailability, it was loaded on the zein-lecithin nanocomposite, which was fabricated by the antisolvent coprecipitation method.
12 citations
TL;DR: Higher FF BPA levels were associated with the higher counts of GVs and oocytes, while oocytes with higher maturity can be achieved in lower levels of BPA in the serum of patients.
Abstract: Objective: To assess the correlation between the levels of BPA in the serum and follicular fluid (FF) using oocyte morphology. Materials and methods: In this cross-sectional research, oocyte, FF, and serum samples were obtained from a sample population consisting of 90 women undergone in vitro fertilization in Ganjavian Hospital in Dezful, Iran during October 2017-March 2018. The ELISA kit was utilized for the measurement of the BPA levels. In addition, oocyte morphology simultaneous with inverted optical microscopy. Results: Follicular fluid BPA levels had no significant effect on MII oocytes (p ≥ 0.05). However, the mean levels of degenerated oocytes and germinal vesicle (GV) were significantly higher in the women with high BPA levels in the FF (p ≤ 0.05). Moreover, the mean counts of MII oocytes and oocytes were significantly higher in the women with serum BPA levels of ≤ 50 ng/ml (p ≤ 0.05), while the mean count of GV oocytes was significantly higher in the women with serum BPA levels of ≥ 150 ng/ml (p ≤ 0.05). Conclusion: According to the results, higher FF BPA levels were associated with the higher counts of GVs and oocytes, while oocytes with higher maturity can be achieved in lower levels of BPA in the serum of patients.
10 citations
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TL;DR: Preclinical evidence is provided that different dietary polyphenols such as rosmarinic acid, ellagic acid, and cinnamic aldehyde can exert neuroprotective and pro-cognitive activities through different molecular mechanisms including the modulation of pro-oxidant and antioxidant machinery as well as inflammatory status.
Abstract: Cognitive impairment, also known as cognitive decline, can occur gradually or suddenly and can be temporary or more permanent. It represents an increasingly important public health problem and can depend on normal aging or be linked to different neurodegenerative disorders, including Alzheimer’s disease (AD). It is now well-established that lifestyle factors including dietary patterns play an important role in healthy aging as well as in the prevention of cognitive decline in later life. Among the natural compounds, dietary polyphenols including phenolic acids have been recently the focus of major attention, with their supplementation being associated with better cognitive status and prevention of cognitive decline. Despite their therapeutic potential, human studies investigating the relation between phenolic acids intake and cognitive outcomes are rather scarce. In this review, we provide preclinical evidence that different dietary polyphenols such as rosmarinic acid, ellagic acid, and cinnamic aldehyde can exert neuroprotective and pro-cognitive activities through different molecular mechanisms including the modulation of pro-oxidant and antioxidant machinery as well as inflammatory status. Future and more numerous in vivo studies are needed to strengthen the promising results obtained at the preclinical level. Despite the excellent pharmacokinetic properties of phenolic acids, which are able to be accumulated in the brain at pharmacologically relevant levels, future studies should also identify which among the different metabolites produced as a consequence of phenolic acids’ consumption may be responsible for the potential neuroprotective effects of this subgroup of polyphenols.
57 citations
TL;DR: A review of magnetic nanoparticles in cancer theranostics can be found in this article, where the authors consolidate the recent improvements in MNPs for clinical applications as well as discuss the future research prospects and potential of MNPs.
55 citations
TL;DR: The current work's data confirms that EA could potentially serve as a novel, promising, and accessible protective agent against diabetes‐associated behavioral deficits, owing to its anti‐hyperglycemic, anti‐inflammatory, and neurotrophic properties.
51 citations
TL;DR: Ellagic acid (EA) is a dietary polyphenol present in various fruits, vegetables, herbs, and nuts as discussed by the authors, which has attracted considerable attention because of its vast range of biological activities as well as its numerous molecular targets.
47 citations
TL;DR: A review of the health-promoting effects of ellagic acid, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic compound in the treatment of several human diseases is presented in this paper .
Abstract: Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
44 citations