H
Houslay
Researcher at University of Glasgow
Publications - 3
Citations - 434
Houslay is an academic researcher from University of Glasgow. The author has contributed to research in topics: Phosphodiesterase & Interleukin 12. The author has an hindex of 3, co-authored 3 publications receiving 379 citations.
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Journal ArticleDOI
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Peter H. Schafer,Anastasia Parton,Anita Gandhi,Lori Capone,Mary Adams,Lei Wu,Justin B. Bartlett,Loveland Ma,Amos Gilhar,Cheung Yf,George S. Baillie,Houslay,Man Hw,G. W. Muller,D. I. Stirling +14 more
TL;DR: The inhibitory effects of apremilast on pro‐inflammatory responses of human primary peripheral blood mononuclear cells, polymorphonuclear Cells, natural killer cells and epidermal keratinocytes were explored in vitro, and in a preclinical model of psoriasis.
Journal ArticleDOI
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release
Wee Kiat Ong,Fiona M. Gribble,Frank Reimann,Martin J. Lynch,Houslay,George S. Baillie,Brian L. Furman,Nigel J. Pyne +7 more
TL;DR: In this paper, the effects of rolipram, a selective PDE4 inhibitor both in vivo and in vitro and stably overexpressed catalytically inactive PDE 4D5 (D556A-PDE4D5) mutant in vitro on GLP-1 release were investigated.
Journal ArticleDOI
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
TL;DR: This work has developed and pioneered the concept that a major function of this N-terminal region is to confer intracellular targeting of particular PDE4 isoforms on specific signalling complexes and intrACEllular locations.