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Hsi-Chung Chen

Bio: Hsi-Chung Chen is an academic researcher from National Taiwan University. The author has contributed to research in topics: Bipolar disorder & Population. The author has an hindex of 21, co-authored 88 publications receiving 1773 citations. Previous affiliations of Hsi-Chung Chen include National Yang-Ming University & Memorial Hospital of South Bend.


Papers
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Journal ArticleDOI
TL;DR: In this article, a systematic review with meta-analysis of randomised trials showed that participants who were randomised to an exercise program had a better global Pittsburgh Sleep Quality Index score, with a standardised mean difference (SMD) of 0.47 (95% CI 0.08 to 0.86).

463 citations

Journal ArticleDOI
Liping Hou1, Urs Heilbronner2, Urs Heilbronner3, Franziska Degenhardt4, Mazda Adli5, Kazufumi Akiyama6, Nirmala Akula1, Raffaella Ardau, Bárbara Arias7, Lena Backlund8, Claudio E. M. Banzato9, Antoni Benabarre7, Susanne Bengesser10, Abesh Kumar Bhattacharjee11, Joanna M. Biernacka12, Armin Birner10, Clara Brichant-Petitjean13, Elise T. Bui1, Pablo Cervantes14, Guo-Bo Chen15, Hsi-Chung Chen16, Caterina Chillotti, Sven Cichon17, Sven Cichon4, Scott R. Clark18, Francesc Colom7, David A. Cousins19, Cristiana Cruceanu20, Piotr M. Czerski21, Clarissa de Rosalmeida Dantas9, Alexandre Dayer22, Bruno Etain23, Peter Falkai3, Andreas J. Forstner4, Louise Frisén8, Janice M. Fullerton24, Janice M. Fullerton25, Sébastien Gard, Julie Garnham26, Fernando S. Goes27, Paul Grof, Oliver Gruber2, Ryota Hashimoto28, Joanna Hauser21, Stefan Herms4, Stefan Herms17, Per Hoffmann4, Per Hoffmann17, Andrea Hofmann4, Stéphane Jamain23, Esther Jiménez7, Jean-Pierre Kahn29, Layla Kassem1, Sarah Kittel-Schneider30, Sebastian Kliwicki21, Barbara König, Ichiro Kusumi31, N. Lackner10, Gonzalo Laje1, Mikael Landén32, Mikael Landén33, Catharina Lavebratt8, Marion Leboyer, Susan G. Leckband8, Susan G. Leckband34, Carlos Jaramillo35, Glenda MacQueen36, Mirko Manchia37, Mirko Manchia26, Lina Martinsson32, Manuel Mattheisen38, Michael McCarthy34, Susan L. McElroy39, Marina Mitjans7, Francis M. Mondimore27, Palmiero Monteleone40, Palmiero Monteleone41, Caroline M. Nievergelt11, Markus M. Nöthen4, Urban Ösby8, Norio Ozaki42, Roy H. Perlis43, Andrea Pfennig44, Daniela Reich-Erkelenz3, Guy A. Rouleau45, Peter R. Schofield25, Peter R. Schofield24, K Oliver Schubert18, Barbara W. Schweizer27, Florian Seemüller3, Giovanni Severino37, Tatyana Shekhtman46, Tatyana Shekhtman11, Paul D. Shilling11, Kazutaka Shimoda6, Christian Simhandl, Claire Slaney26, Jordan W. Smoller43, Alessio Squassina37, Thomas Stamm5, Pavla Stopkova47, Sarah K. Tighe48, Sarah K. Tighe49, Alfonso Tortorella40, Gustavo Turecki20, Julia Volkert30, Stephanie H. Witt50, Adam Wright24, L. Trevor Young51, Peter P. Zandi27, James B. Potash49, J. Raymond DePaulo27, Michael Bauer44, Eva Z. Reininghaus10, Tomas Novak47, Jean-Michel Aubry22, Mario Maj40, Bernhard T. Baune18, Philip B. Mitchell24, Eduard Vieta7, Mark A. Frye12, Janusz K. Rybakowski21, Po-Hsiu Kuo16, Tadafumi Kato52, Maria Grigoroiu-Serbanescu, Andreas Reif30, Maria Del Zompo37, Frank Bellivier13, Martin Schalling8, Naomi R. Wray15, John R. Kelsoe46, John R. Kelsoe11, Martin Alda47, Martin Alda26, Marcella Rietschel50, Francis J. McMahon1, Thomas G. Schulze 
United States Department of Health and Human Services1, University of Göttingen2, Ludwig Maximilian University of Munich3, University of Bonn4, Charité5, Dokkyo Medical University6, University of Barcelona7, Karolinska University Hospital8, State University of Campinas9, Medical University of Graz10, University of California, San Diego11, Mayo Clinic12, Paris Diderot University13, McGill University Health Centre14, University of Queensland15, National Taiwan University16, University Hospital of Basel17, University of Adelaide18, Newcastle University19, Douglas Mental Health University Institute20, Poznan University of Medical Sciences21, Geneva College22, French Institute of Health and Medical Research23, University of New South Wales24, Neuroscience Research Australia25, Dalhousie University26, Johns Hopkins University27, Osaka University28, University of Lorraine29, Goethe University Frankfurt30, Hokkaido University31, Karolinska Institutet32, University of Gothenburg33, Veterans Health Administration34, University of Antioquia35, University of Calgary36, University of Cagliari37, Aarhus University38, University of Cincinnati39, University of Naples Federico II40, University of Salerno41, Nagoya University42, Harvard University43, Dresden University of Technology44, Montreal Neurological Institute and Hospital45, United States Department of Veterans Affairs46, National Institutes of Health47, Roy J. and Lucille A. Carver College of Medicine48, University of Iowa49, Heidelberg University50, University of Toronto51, RIKEN Brain Science Institute52
TL;DR: A genome-wide association study of lithium response in 2,563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen); the largest attempted so far finds a single locus of four linked SNPs on chromosome 21 met genome- wide significance criteria for association with lithium response.

258 citations

Journal ArticleDOI
Azmeraw T. Amare1, Klaus Oliver Schubert2, Klaus Oliver Schubert1, Liping Hou3, Scott R. Clark1, Sergi Papiol4, Urs Heilbronner5, Urs Heilbronner4, Franziska Degenhardt6, Fasil Tekola-Ayele7, Yi-Hsiang Hsu8, Yi-Hsiang Hsu9, Tatyana Shekhtman10, Mazda Adli11, Nirmala Akula3, Kazufumi Akiyama12, Raffaella Ardau, Bárbara Arias13, Jean-Michel Aubry14, Lena Backlund15, Abesh Kumar Bhattacharjee10, Frank Bellivier16, Antonio Benabarre13, Susanne Bengesser17, Joanna M. Biernacka18, Armin Birner17, Clara Brichant-Petitjean16, Pablo Cervantes19, Hsi-Chung Chen20, Caterina Chillotti, Sven Cichon6, Sven Cichon21, Cristiana Cruceanu22, Piotr M. Czerski23, Nina Dalkner17, Alexandre Dayer14, Maria Del Zompo24, J. Raymond DePaulo25, Bruno Etain16, Peter Falkai4, Andreas J. Forstner21, Andreas J. Forstner6, Andreas J. Forstner26, Louise Frisén15, Mark A. Frye18, Janice M. Fullerton27, Janice M. Fullerton28, Sébastien Gard, Julie Garnham29, Fernando S. Goes25, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto30, Joanna Hauser23, Stefan Herms21, Stefan Herms6, Per Hoffmann21, Per Hoffmann6, Andrea Hofmann6, Stéphane Jamain16, Esther Jiménez13, Jean-Pierre Kahn31, Layla Kassem3, Po-Hsiu Kuo20, Tadafumi Kato32, John R. Kelsoe10, Sarah Kittel-Schneider33, Sebastian Kliwicki23, Barbara König, Ichiro Kusumi34, Gonzalo Laje3, Mikael Landén35, Mikael Landén36, Catharina Lavebratt15, Marion Leboyer37, Susan G. Leckband38, Alfonso Tortorella39, Mirko Manchia24, Mirko Manchia29, Lina Martinsson35, Michael McCarthy10, Michael McCarthy38, Susan L. McElroy40, Francesc Colom13, Marina Mitjans41, Marina Mitjans42, Francis M. Mondimore25, Palmiero Monteleone43, Palmiero Monteleone44, Caroline M. Nievergelt10, Markus M. Nöthen6, Tomas Novak7, Claire O'Donovan29, Norio Ozaki45, Urban Ösby15, Andrea Pfennig46, James B. Potash25, Andreas Reif32, Eva Z. Reininghaus17, Guy A. Rouleau47, Janusz K. Rybakowski33, Martin Schalling15, Peter R. Schofield28, Peter R. Schofield27, Barbara W. Schweizer25, Giovanni Severino24, Paul D. Shilling15, Katzutaka Shimoda48, Christian Simhandl, Claire Slaney29, Alessio Squassina24, Thomas Stamm11, Pavla Stopkova7, Mario Maj44, Gustavo Turecki22, Eduard Vieta13, Julia Volkert33, Stephanie H. Witt49, Adam Wright27, Peter P. Zandi25, Philip B. Mitchell27, Michael Bauer46, Martin Alda29, Marcella Rietschel49, Francis J. McMahon3, Thomas G. Schulze, Bernhard T. Baune1 
TL;DR: Evidence is provided for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD, suggesting the potential for translational research aimed at personalized prescribing of lithium.
Abstract: Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). Objectives To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association. Design, Setting, and Participants A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at differentPvalue thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017. Main Outcomes and Measures Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained. Results Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a thresholdP Conclusions and Relevance This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.

124 citations

Journal ArticleDOI
TL;DR: The BSRS-5 is an effective screening instrument for the identification of psychiatric morbidity in hospital-based health screening settings and should be retained in future studies.

98 citations

Journal ArticleDOI
TL;DR: Pathway analyses revealed that pentose phosphate and starch and sucrose metabolism processes were important pathways for depression via microbiota functions, and microbiota targets for depression that are independent of fat intake were revealed.

88 citations


Cited by
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TL;DR: Following the new guidelines for therapeutic drug monitoring in psychiatry holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
Abstract: Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities. Non-response at therapeutic doses, uncertain drug adherence, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM. However, the potential benefits of TDM to optimize pharmacotherapy can only be obtained if the method is adequately integrated in the clinical treatment process. To supply treating physicians and laboratories with valid information on TDM, the TDM task force of the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued their first guidelines for TDM in psychiatry in 2004. After an update in 2011, it was time for the next update. Following the new guidelines holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.

827 citations

Journal ArticleDOI
TL;DR: A meta-analytical review of the effects of acute and regular exercise on sleep, incorporating a range of outcome and moderator variables, reveals that acute exercise has small beneficial effects on total sleep time, sleep onset latency, sleep efficiency, stage 1 sleep, and slow wave sleep.
Abstract: A significant body of research has investigated the effects of physical activity on sleep, yet this research has not been systematically aggregated in over a decade. As a result, the magnitude and moderators of these effects are unclear. This meta-analytical review examines the effects of acute and regular exercise on sleep, incorporating a range of outcome and moderator variables. PubMed and PsycINFO were used to identify 66 studies for inclusion in the analysis that were published through May 2013. Analyses reveal that acute exercise has small beneficial effects on total sleep time, sleep onset latency, sleep efficiency, stage 1 sleep, and slow wave sleep, a moderate beneficial effect on wake time after sleep onset, and a small effect on rapid eye movement sleep. Regular exercise has small beneficial effects on total sleep time and sleep efficiency, small-to-medium beneficial effects on sleep onset latency, and moderate beneficial effects on sleep quality. Effects were moderated by sex, age, baseline physical activity level of participants, as well as exercise type, time of day, duration, and adherence. Significant moderation was not found for exercise intensity, aerobic/anaerobic classification, or publication date. Results were discussed with regards to future avenues of research and clinical application to the treatment of insomnia.

729 citations

Journal ArticleDOI
Harry Crook1, Sanara Raza1, Joseph Nowell1, Megan Young1, Paul Edison1 
26 Jul 2021-BMJ
TL;DR: In this article, a review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure, including fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of posttraumatic stress disorder, muscle pain, concentration problems, and headache.
Abstract: Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is now coined long covid by recognized research institutes. Studies have shown that long covid can affect the whole spectrum of people with covid-19, from those with very mild acute disease to the most severe forms. Like acute covid-19, long covid can involve multiple organs and can affect many systems including, but not limited to, the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. The symptoms of long covid include fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of post-traumatic stress disorder, muscle pain, concentration problems, and headache. This review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure. Risk factors for acute covid-19 and long covid and possible therapeutic options are also discussed.

679 citations