H
Hsuan-Ying Huang
Researcher at Chang Gung University
Publications - 162
Citations - 5964
Hsuan-Ying Huang is an academic researcher from Chang Gung University. The author has contributed to research in topics: Cancer & Nasopharyngeal carcinoma. The author has an hindex of 38, co-authored 150 publications receiving 5173 citations. Previous affiliations of Hsuan-Ying Huang include Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
Chia Hsin Chan,Chien Feng Li,Chien Feng Li,Wei Lei Yang,Wei Lei Yang,Yuan Gao,Yuan Gao,Szu Wei Lee,Szu Wei Lee,Zizhen Feng,Hsuan-Ying Huang,Kelvin K C Tsai,Leo G. Flores,Yiping Shao,John D. Hazle,Dihua Yu,Dihua Yu,Wenyi Wei,Dos D. Sarbassov,Dos D. Sarbassov,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung,Keiichi I. Nakayama,Hui Kuan Lin,Hui Kuan Lin +25 more
TL;DR: It is suggested that distinct E3 ligases are utilized by diverse growth factors for Akt activation and that targeting glycolysis sensitizes Her2-positive tumors to Herceptin treatment.
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Ewing Sarcomas With p53 Mutation or p16/p14ARF Homozygous Deletion: A Highly Lethal Subset Associated With Poor Chemoresponse
Hsuan-Ying Huang,Peter B. Illei,Zhiquan Zhao,Madhu Mazumdar,Andrew G. Huvos,John H. Healey,Leonard H. Wexler,Richard Gorlick,Paul A. Meyers,Marc Ladanyi +9 more
TL;DR: Alterations in p53 or p16/p14ARF are found in a fourth of ES cases and define a subset with highly aggressive behavior and poor chemoresponse, which is the first combined prognostic analysis of these three molecular parameters in ES.
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Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems.
TL;DR: The data statistically validated the previous impression that even the blandest LGMFS still carries a recurrent potential that cannot be foreseen by either different grading schemes or other clinicopathologic parameters.
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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
Chia Hsin Chan,Szu Wei Lee,Szu Wei Lee,Chien Feng Li,Jing Wang,Wei Lei Yang,Wei Lei Yang,Ching Yuan Wu,Ching Yuan Wu,Juan Wu,Juan Wu,Keiichi I. Nakayama,Hong-Yo Kang,Hsuan-Ying Huang,Mien Chie Hung,Pier Paolo Pandolfi,Hui Kuan Lin,Hui Kuan Lin +17 more
TL;DR: Insight is provided into how oncogenic Skp2 and Myc coordinate to induce RhoA transcription and a novel SCF–Skp2 E3-ligase-independent function for oncogens Skp 2 in transcription and cancer metastasis is established.
Journal Article
Absence of a Telomere Maintenance Mechanism as a Favorable Prognostic Factor in Patients with Osteosarcoma
Gary A. Ulaner,Hsuan-Ying Huang,Jesse E. Otero,Zhiquan Zhao,Leah Ben-Porat,Jaya M. Satagopan,Richard Gorlick,Paul A. Meyers,John H. Healey,Andrew G. Huvos,Andrew R. Hoffman,Marc Ladanyi +11 more
TL;DR: The absence of a detectable TMM may identify a favorable clinical subset of OS patients and the likelihood of detecting correlations between TMMs and clinical outcome in studies of certain other tumor types might be improved if, in addition to TA, ALT is included in future analyses.