H
Hua-Xin Liao
Researcher at Jinan University
Publications - 271
Citations - 20932
Hua-Xin Liao is an academic researcher from Jinan University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 73, co-authored 269 publications receiving 18914 citations. Previous affiliations of Hua-Xin Liao include Lynn University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
Barton F. Haynes,Peter B. Gilbert,M. Juliana McElrath,Susan Zolla-Pazner,Georgia D. Tomaras,S. Munir Alam,David T. Evans,David C. Montefiori,Chitraporn Karnasuta,Ruengpueng Sutthent,Hua-Xin Liao,Anthony L. DeVico,George K. Lewis,Constance Williams,Abraham Pinter,Youyi Fong,Holly Janes,Allan C. deCamp,Yunda Huang,Mangala Rao,Erik Billings,Nicos Karasavvas,Merlin L. Robb,Viseth Ngauy,Mark de Souza,Robert Paris,Guido Ferrari,Robert T. Bailer,Kelly A. Soderberg,Charla Andrews,Phillip W. Berman,Nicole Frahm,Stephen C. De Rosa,Michael D. Alpert,Nicole L. Yates,Xiaoying Shen,Richard A. Koup,Punnee Pitisuttithum,Jaranit Kaewkungwal,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Nelson L. Michael,Jerome H. Kim +42 more
TL;DR: V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection.
Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies
Barton F. Haynes,Judith A. Fleming,E. William St. Clair,Herman Katinger,Gabriela Stiegler,Renate Kunert,James E. Robinson,Richard M. Scearce,Kelly Plonk,Herman F. Staats,Thomas L. Ortel,Hua-Xin Liao,S. Munir Alam +12 more
TL;DR: It is demonstrated that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin, which may have important implications for generating effective neutralizing antibody responses by using HIV- 1 vaccines.
Journal ArticleDOI
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
Georgia D. Tomaras,Nicole L. Yates,Pinghuang Liu,Li Qin,Genevieve G. Fouda,Leslie L. Chavez,Allan C. deCamp,Robert Parks,Vicki C Ashley,Judith T. Lucas,Myron S. Cohen,Joseph J. Eron,Charles B. Hicks,Hua-Xin Liao,Steven G. Self,Gary Landucci,Donald N. Forthal,Kent J. Weinhold,Brandon F. Keele,Beatrice H. Hahn,Michael L. Greenberg,Lynn Morris,Salim S. Abdool Karim,William A. Blattner,David C. Montefiori,George M. Shaw,Alan S. Perelson,Barton F. Haynes +27 more
TL;DR: It is demonstrated that the first IgM and IgG antibodies induced by transmitted HIV-1 are capable of binding virions but have little impact on acute-phase viremia at the timing and magnitude that they occur in natural infection.
Journal ArticleDOI
Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
Mattia Bonsignori,Kwan Ki Hwang,Xi Chen,Chun Yen Tsao,Lynn Morris,Elin S. Gray,Dawn J. Marshall,John A. Crump,Saidi Kapiga,Noel E. Sam,Faruk Sinangil,Marie Pancera,Yang Yongping,Baoshan Zhang,Jiang Zhu,Peter D. Kwong,Sijy O'Dell,John R. Mascola,Lan Wu,Gary J. Nabel,Sanjay Phogat,Michael S. Seaman,John F. Whitesides,M. Anthony Moody,Garnett Kelsoe,Xinzhen Yang,Joseph Sodroski,George M. Shaw,David C. Montefiori,Thomas B. Kepler,Georgia D. Tomaras,S. Munir Alam,Hua-Xin Liao,Barton F. Haynes +33 more
TL;DR: A clonal lineage of four V2/V3 conformational epitope broadly neutralizing antibodies from an African HIV-1-infected broad neutralizer is identified and their common reverted unmutated ancestor (RUA) antibodies are inferred.