Showing papers by "Hua Zhang published in 2022"
TL;DR: In this paper , an isoreticular series of 2D covalent organic frameworks (COFs) with the kgd topology and controllable pore size is synthesized by employing a C6-symmetric aldehyde, i.e., hexa(4-formylphenyl)benzene (HFPB), and C 3-symetric amines, as building units.
Abstract: Two-dimensional (2D) covalent organic frameworks (COFs) possess designable pore architectures but limited framework topologies. Until now, 2D COFs adopting the kgd topology with ordered and rhombic pore geometry have rarely been reported. Here, an isoreticular series of 2D COFs with the kgd topology and controllable pore size is synthesized by employing a C6-symmetric aldehyde, i.e., hexa(4-formylphenyl)benzene (HFPB), and C3-symmetric amines i.e., tris(4-aminophenyl)amine (TAPA), tris(4-aminophenyl)trazine (TAPT), and 1,3,5-tris[4-amino(1,1-biphenyl-4-yl)]benzene (TABPB), as building units, referred to as HFPB-TAPA, HFPB-TAPT, and HFPB-TABPB, respectively. The micropore dimension down to 6.7 Å is achieved in HFPB-TAPA, which is among the smallest pore size of reported 2D COFs. Impressively, both the in-plane network and stacking sequence of the 2D COFs can be clearly observed by low-dose electron microscopy. Integrating the unique kgd topology with small rhombic micropores, these 2D COFs are endowed with both short molecular diffusion length and favorable host-guest interaction, exhibiting potential for drug delivery with high loading and good release control of ibuprofen.
30 citations
TL;DR: In this paper , a review summarizes the most recent developments in phase engineering of metal nanocatalysts for the electrochemical CO2 reduction reaction (CO2RR) offers a green and sustainable process to convert CO2 into valuable chemical stocks and fuels.
25 citations
20 citations
TL;DR: In this article , a facile one-pot wet-chemical method was proposed to synthesize three types of amorphous SnO2-encapsulated crystalline Cu heterostructures.
Abstract: Controlling the architectures and crystal phases of metal@semiconductor heterostructures is very important for modulating their physicochemical properties and enhancing their application performances. Here, a facile one‐pot wet‐chemical method to synthesize three types of amorphous SnO2‐encapsulated crystalline Cu heterostructures, i.e., hemicapsule, yolk–shell, and core–shell nanostructures, in which unconventional crystal phases (e.g., 2H, 4H, and 6H) and defects (e.g., stacking faults and twin boundaries) are observed in the crystalline Cu cores, is reported. The hemicapsule Cu@SnO2 heterostructures, with voids that not only expose the Cu core with unconventional phases but also retain the interface between Cu and SnO2, show an excellent electrocatalytic CO2 reduction reaction (CO2RR) selectivity toward the production of CO and formate with high Faradaic efficiency (FE) above 90% in a wide potential window from −1.05 to −1.55 V (vs reversible hydrogen electrode (RHE)), and the highest FE of CO2RR (95.3%) is obtained at −1.45 V (vs RHE). This work opens up a new way for the synthesis of new heterostructured nanomaterials with promising catalytic application.
16 citations
TL;DR: In this article , in vitro digestion, human colonic adenocarcinoma cell line (Caco-2/macrophage cell lines of the murine origin (Raw264.7) coculture model was established to investigate the release of polyphenols, absorption, and transport of digestive products and their effects on inflammation and intestinal barrier.
Abstract: Green pea hulls are a byproduct of the processing of green pea and are rich in phenolic substances. In the present study, in vitro digestion, human colonic adenocarcinoma cell line (Caco-2) monolayer, and the Caco-2/macrophage cell lines of the murine origin (Raw264.7) coculture model were established to investigate the release of polyphenols, absorption, and transport of digestive products and their effects on inflammation and intestinal barrier. During the digestive process, polyphenols were constantly released from the pea hulls, reaching the maximum amount in the small intestine (total phenolic content (TPC): 5.41 ± 0.04 mg gallic acid (GAE)/g dry weight (DW)), and the digestive products (800 μg/mL) could reduce the secretion of NO (50.9%), IL-6 (50.6%), and TNF-α (24.6%) and inhibit the mRNA expression of cyclooxygenase-2 (COX-2) (37.2%) and inducible nitric oxide synthase (iNOS) (91.1%) compared with the lipopolysaccharide (LPS) group. A total of 12 phenolic components were quantified by ultraperformance liquid chromatography-linear ion trap orbitrap tandem mass spectrometry (UHPLC-LTQ-OrbiTrap-MS) technology. Kaempferol trihexoside in digestive products could be absorbed and transported (1.25 ± 0.13 ng quercetin/mL). The digestive products could promote the expression of claudin-1 (210.8%), occludin (64.9%), and zonulin occludin-1 (ZO-1) (52.0%) compared with the LPS group and exert anti-inflammatory effects after being absorbed. The results indicated that pea hull polyphenols could be continuously released and absorbed to play a positive role in protecting the intestinal barrier and anti-inflammatory activity.
10 citations
TL;DR: In this paper , a peptide-photosensitizer conjugate (PPC) was designed for breast cancer photoimmunotherapy, which consisted of a PD-L1 antagonist peptide (CVRARTR), an MMP-2 specific cleavable sequence, a self-assembling motif, and the photosensitizers Purpurin 18.
10 citations
TL;DR: In this article , the authors performed transcriptome analysis to reveal the response mechanism of Pinctada fucata to long-term high-temperature stress, and found that the genes were mainly associated with defence mechanisms, phagosome signalling, cytoskeleton, posttranslational modification, protein turnover and chaperones under heat stress.
10 citations
9 citations
TL;DR: House dust mites remain the most important allergen in Chinese individuals with asthma and/or rhinitis, and sensitization to pollens, especially Artemisia vulgaris, showed the greatest increase in the north.
Abstract: Abstract Background Little is known about the changes in allergen sensitization in China secondary to the environmental variations over the past decade. We aimed at investigating the variations in sensitization among asthma and/or rhinitis patients in China between 2008 and 2018. Methods This study analyzed cross‐sectional data from national surveys conducted in China in 2008 and 2018. After finishing the questionnaire, participants underwent serum specific IgE measurements. A total of 2322 and 2798 patients were enrolled in 2008 and 2018, respectively. The significance of differences in sensitization rates among four regions of China were assessed. Correlation analysis was used to identify the associations of sensitization with climate change and planting of Artemisia desertorum between the two surveys. Results Compared with 2008, the general sensitization rate to mites significantly increased in 2018, which ranked highest among all tested allergens. Sensitization to pollens, especially Artemisia vulgaris, showed the greatest increase in the north. The annual mean temperature, rainfall and relative humidity in all four regions, and the Artemisia desertorum coverage in the northeastern area, increased significantly in 2018 as compared with 2008. From 2008 to 2018, an increase in Dermatophagoides pteronyssinus sensitization was significantly associated with an increase in relative humidity (r = 0.54, p = 0.037). The increase in A. vulgaris sensitization was significantly associated with the increase in the A. desertorum planting area (r = 0.67, p = 0.006) and with a decrease in rainfall (r = −0.59, p = 0.021). Conclusions House dust mites remain the most important allergen in Chinese individuals with asthma and/or rhinitis. Pollen sensitization dramatically increased in northern China. Increases in sensitization to dust mites and Artemisia were related to the increases in humidity and planting area of A. desertorum.
9 citations
TL;DR: In this article , a thermal-hydraulic coupled simulation approach is proposed to simulate and control multi-room radiator heating systems, where the temperature distribution and thermal capacity of the radiator, as well as the hydraulic characteristics of the radiators are considered.
9 citations
TL;DR: In this article , a facile, one-step salt-assisted general strategy is reported for the controlled phase transformation of commercially available TMDs with conventional 2H phase, yielding a large amount of metastable 1T′-phase TMD alloys, including WS2, WSe2, MoS2, and MoSe2.
Abstract: Phase engineering of nanomaterials (PEN) has demonstrated great potential in the fields of catalysis, electronics, energy storage and conversion, and condensed matter physics. Recently, transition metal dichalcogenides (TMDs) with unconventional metastable phases (e.g., 1T and 1T′) have attracted increasing research interest due to their unique and appealing physicochemical properties. However, there is still a lack of a simple, universal, and controlled method for the preparation of large‐scale and high‐purity unconventional‐phase TMD crystals, restricting their further fundamental study and practical applications. Here, a facile, one‐step salt‐assisted general strategy is reported for the controlled phase transformation of commercially available TMDs with conventional 2H phase, yielding a large amount of metastable 1T′‐phase TMDs, including WS2, WSe2, MoS2, and MoSe2. It is found that the easily accessible metal salts, such as K2C2O4·H2O, K2CO3, Na2CO3, Rb2CO3, Cs2CO3, KHCO3, NaHCO3, and NaC2O4, can be used to assist the 2H‐to‐1T′ phase transformation, greatly simplifying the synthetic process for producing metastable 1T′‐TMDs. Importantly, this method can also be used to prepare 1T′‐TMD alloys, such as 1T′‐WS2xSe2(1−x). This newly developed strategy is robust and highly effective, which can also be used for the phase engineering of other materials with various polymorphs.
TL;DR: In this article , the authors summarized the virus detection techniques with an emphasis on the current efforts in fighting again COVID-19 and introduced the preparation methods and properties of 2D materials utilized in biosensors, including graphene, transition metal dichalcogenides (TMDs) and other 2D material.
Abstract: Cost-effective, rapid, and accurate virus detection technologies play key roles in reducing viral transmission. Prompt and accurate virus detection enables timely treatment and effective quarantine of virus carrier, and therefore effectively reduces the possibility of large-scale spread. However, conventional virus detection techniques often suffer from slow response, high cost or sophisticated procedures. Recently, two-dimensional (2D) materials have been used as promising sensing platforms for the high-performance detection of a variety of chemical and biological substances. The unique properties of 2D materials, such as large specific area, active surface interaction with biomolecules and facile surface functionalization, provide advantages in developing novel virus detection technologies with fast response and high sensitivity. Furthermore, 2D materials possess versatile and tunable electronic, electrochemical and optical properties, making them ideal platforms to demonstrate conceptual sensing techniques and explore complex sensing mechanisms in next-generation biosensors. In this review, we first briefly summarize the virus detection techniques with an emphasis on the current efforts in fighting again COVID-19. Then, we introduce the preparation methods and properties of 2D materials utilized in biosensors, including graphene, transition metal dichalcogenides (TMDs) and other 2D materials. Furthermore, we discuss the working principles of various virus detection technologies based on emerging 2D materials, such as field-effect transistor-based virus detection, electrochemical virus detection, optical virus detection and other virus detection techniques. Then, we elaborate on the essential works in 2D material-based high-performance virus detection. Finally, our perspective on the challenges and future research direction in this field is discussed.
TL;DR: In this paper , a unique model of adult ovarian angiogenesis implies a strategy to extend female reproductive life span, and a strategy is proposed to prolong the life span of women.
Abstract: Unique model of adult ovarian angiogenesis implies a strategy to extend female reproductive life span.
TL;DR: In this paper , a triangular solar air collector assisted air source heat pump (TSAHP) for rural residence heating is presented, and three working modes of the TSAHP including preheating, series and parallel modes are investigated, and corresponding mathematical models were established and verified.
TL;DR: The C-N borylation of arylhydrazine hydrochlorides with bis(pinacolato)diboron was achieved under photochemical and electrochemical conditions, respectively, and provides two efficient and mild transition-metal-free synthetic routes towards aRYl boronate esters from easily available aryLhydrazines.
TL;DR: An efficient Ir-catalyzed enantioselective intramolecular allylic substitution reaction of 2-tosylhydrazono or hydroxyimino carbonates for the synthesis of pyrazolines and isoxazolines has been achieved in high yield as discussed by the authors .
Abstract: An efficient Ir-catalyzed enantioselective intramolecular allylic substitution reaction of 2-tosylhydrazono or hydroxyimino carbonates for the synthesis of pyrazolines and isoxazolines has been achieved. The products were obtained in high yield...
TL;DR: A near-infrared twisted intramolecular charge transfer (TICT) fluorescent probe YON was used to monitor trace changes of mtDNA in living cells and could be used to evaluate the health of cells by monitoring microchanges of mt DNA, enabling the ultrasensitive evaluation of apoptosis.
Abstract: Mitochondrial DNA (mtDNA) as a class of important genetic material is easily damaged, which can result in a series of metabolic diseases, hereditary disease, and so on. mtDNA is an ultrasensitive indicator for the health of living cells due to the extremely short physiological response time of mtDNA toward damage (ca. 5.0 min). Therefore, the development of specific ultrasensitive fluorescent probes that can in real-time monitor mtDNA in vivo are of great value. With this research, we developed a near-infrared twisted intramolecular charge transfer (TICT) fluorescent probe YON. YON is a thread-like molecule with an A-π-D-π-A structure, based on the dicyanoisophorone fluorophore. The molecular design of YON enabled the specific binding with dsDNA (binding constant (K) = 8.5 × 105 M-1) within 1.3 min. And the appropriate water-oil amphiphilicity makes YON significantly accumulate in the mitochondria, enabling the specific binding to mtDNA. The fluorescence intensity at 640 nm of YON enhanced linearly with increasing concentrations of mtDNA. Dicyanoisophorone as the strong electron-withdrawing group that was introduced into both ends of the molecule resulted in YON being a classic quadrupole, so it could ultrasensitively detect trace mtDNA. The minimum detection limit was 71 ng/mL. Moreover, the large Stokes shift (λex = 435 nm, λem = 640 nm) makes YON suitable for "interference-free" imaging of mtDNA. Therefore, YON was used to monitor trace changes of mtDNA in living cells; more importantly, it could be used to evaluate the health of cells by monitoring microchanges of mtDNA, enabling the ultrasensitive evaluation of apoptosis.
TL;DR: In this paper , the key secreted factor KIT ligand from pregranulosa cells was removed from preGCs to reveal distinct patterns of activation and growth associated with the two waves of follicles in mouse ovary.
Abstract: Abstract Background Ovarian follicles, which are the basic units of female reproduction, are composed of oocytes and surrounding somatic (pre) granulosa cells (GCs). A recent study revealed that signaling in somatic preGCs controlled the activation (initial recruitment) of follicles in the adult ovaries, but it is also known that there are two waves of follicle with age-related heterogeneity in their developmental dynamics in mammals. Although this heterogeneity was proposed to be crucial for female reproduction, our understanding of how it arises and its significance is still elusive. Results In the current study, by deleting the key secreted factor KIT ligand from preGCs and analyzing the follicle cell developmental dynamics, we revealed distinct patterns of activation and growth associated with the two waves of follicles in mouse ovary. Our results confirmed that activation of adult wave follicles is initiated by somatic preGCs and dependent on the KIT ligand. By contrast, activation of first wave follicles, which are awakened from germ cells before follicle formation, can occur in the absence of preGC-secreted KIT ligand in postnatal ovaries and appears to be oocyte-initiated. We also found that the asynchronous activity of phosphatidylinositol 3 kinases (PI3K) signaling and meiotic process in embryonic germ cells lead to the follicle heterogeneity in postnatal ovaries. In addition, we supplied evidence that the time sequence of embryonic germ cell development and its related first wave follicle growth are correlated to the time of puberty onset in females. Conclusion Taken together, our study provides evidence that asynchronous development of embryonic oocytes leads to the heterogeneity of postnatal ovarian follicle activation and development, and affects the timing of onset of puberty in females.
TL;DR: A CFAR detection method is proposed, which transforms the Monte Carlo simulation principle into randomly sampling instantaneous Range–Doppler Matrix (RDM) data, to improve the detection ability of radar for moving targets such as pedestrians and vehicles in the traffic environment.
Abstract: The development of Intelligent Transportation Systems (ITS) puts forward higher requirements for millimeter-wave radar surveillance in the traffic environment, such as lower time delay, higher sensitivity, and better multi-target detection capability. The Constant False Alarm Rate (CFAR) detector plays a vital role in the adaptive target detection of the radar. Still, traditional CFAR detection algorithms use a sliding window to find the target limit radar detection speed and efficiency. In such cases, we propose and discuss a CFAR detection method, which transforms the Monte Carlo simulation principle into randomly sampling instantaneous Range–Doppler Matrix (RDM) data, to improve the detection ability of radar for moving targets such as pedestrians and vehicles in the traffic environment. Compared with conventional methods, simulation and real experiments show that the method breaks through the reference window limitation and has higher detection sensitivity, higher detection accuracy, and lower detection delay. We hope to promote the detection application of millimeter-wave radar in road traffic scenes.
TL;DR: In this paper , the key secreted factor KIT ligand from pregranulosa cells was removed from preGCs to reveal distinct patterns of activation and growth associated with the two waves of follicles in mouse ovary.
Abstract: Abstract Background Ovarian follicles, which are the basic units of female reproduction, are composed of oocytes and surrounding somatic (pre) granulosa cells (GCs). A recent study revealed that signaling in somatic preGCs controlled the activation (initial recruitment) of follicles in the adult ovaries, but it is also known that there are two waves of follicle with age-related heterogeneity in their developmental dynamics in mammals. Although this heterogeneity was proposed to be crucial for female reproduction, our understanding of how it arises and its significance is still elusive. Results In the current study, by deleting the key secreted factor KIT ligand from preGCs and analyzing the follicle cell developmental dynamics, we revealed distinct patterns of activation and growth associated with the two waves of follicles in mouse ovary. Our results confirmed that activation of adult wave follicles is initiated by somatic preGCs and dependent on the KIT ligand. By contrast, activation of first wave follicles, which are awakened from germ cells before follicle formation, can occur in the absence of preGC-secreted KIT ligand in postnatal ovaries and appears to be oocyte-initiated. We also found that the asynchronous activity of phosphatidylinositol 3 kinases (PI3K) signaling and meiotic process in embryonic germ cells lead to the follicle heterogeneity in postnatal ovaries. In addition, we supplied evidence that the time sequence of embryonic germ cell development and its related first wave follicle growth are correlated to the time of puberty onset in females. Conclusion Taken together, our study provides evidence that asynchronous development of embryonic oocytes leads to the heterogeneity of postnatal ovarian follicle activation and development, and affects the timing of onset of puberty in females.
01 Jan 2022-Journal of Materials Chemistry C. Materials for Optical, Magnetic and Electronic Devices
TL;DR: A series of highly polarizable chromophores A-F based on the same bis(N,N-diethyl)aniline donor, the tricyanofuran (TCF) and CF3-Ph-TCF accepter linked via thiophene, alkoxy chains modified thiophenes and extended π-conjugations have been proposed as discussed by the authors .
Abstract: A series of highly polarizable chromophores A-F based on the same bis(N,N-diethyl)aniline donor, the tricyanofuran (TCF) and CF3-Ph-TCF accepter linked via thiophene, alkoxy chains modified thiophene and extended π-conjugations have...
TL;DR: In this article , the growth mechanism and its influence on the phase transition and magnetocaloric effect of FeRh films grown on MgO, LaAlO3, SrTiO3 and PMN-PT substrates were studied.
TL;DR: Wang et al. as discussed by the authors investigated the application of innovative platform doors (IPD) with adjustable vents at side platforms in a subway station, and the results revealed that the ventilation energy consumption is reduced by 19.31-57.25% in different climatic regions by effective utilization of the piston wind in the whole year.
01 May 2022-Materials Science and Engineering A-structural Materials Properties Microstructure and Processing
TL;DR: In this article , a high-throughput gradient thermal compression process was adopted to investigate the effects of thermal deformation parameters on the deformation behavior and microstructure evolution of a rolled AZ31 Mg alloy.
Abstract: A high-throughput gradient thermal compression process was adopted to investigate the effects of thermal deformation parameters on the deformation behavior and microstructure evolution of a rolled AZ31 Mg alloy. The results showed that with increasing deformation degree, the flow stress-strain curves of the double-cone samples compressed along the normal direction (ND), transverse direction (TD), and rolling direction (RD) of rolled Mg alloy rapidly reached their peak value, then decreased gradually, and finally maintained a trend of horizontal change. Under the same strain condition, the dynamic recrystallization (DRX) degree of the double-cone sample increased gradually with increased deformation temperature. Twins were more likely to occur when compression occurred in the TD and RD, rather than along ND. With increasing temperature or strain, the number of twins that formed during compression gradually decreased. At deformation temperatures of 250 °C and 300 °C, continuous dynamic recrystallization was the main DRX mechanism in the double-cone samples compressed along the ND, TD, and RD. Furthermore, the twin-assisted DRX mechanism also occurred in the double-cone samples compressed at 250 °C along the TD and RD. During compression at 350 °C and 400 °C along the ND, TD, and RD, discontinuous dynamic recrystallization occurred in the double-cone samples, indicating that the DRX mechanism changed with increasing compression temperature.
TL;DR: In this paper, a femtosecond transient absorption (fs-TA) spectroscopy was used to measure the multi-color fluorescence of two donor-πacceptor (D-π-A) models based on (2-(4-vinylbenzylidene)malononitrile derivatives.
TL;DR: In this paper , the pollution status and ecological risks of heavy metal elements of Cr, Ni, Cu, Zn, As, Cd, Pb, V, and Co were determined using the enrichment factor (EF), geoaccumulaton index (Igeo), and potential ecological risk index (PERI).
TL;DR: A lateral flow immunoassay (LFIA) with peptide functionalized gold nanoparticles (termed as biotin-ppeptide-AuNPs) has been developed for rapid, semi-quantitative detection of PTP1B activity without using any sophisticated equipment as mentioned in this paper .
TL;DR: In this paper , the authors provide a comprehensive information on the electrochemical point-of-care testing (POCT), including a general aspect of ePADs, enhancement strategies of nanomaterials and potential applications in the fields of environmental monitoring, food safety management and disease diagnosis.
Abstract: Integration of electrochemical detection methods into paper-based analytical devices (PADs) provides a powerful tool for the area of point-of-care testing (POCT) because the electrochemical PADs (termed as ePADs) enable to rapidly determine a broad spectrum of analytes from ions to living cells in a miniaturized, cost-effective and user-friendly manner. Recently, nanomaterials and their composites were extensively introduced in ePADs for improvement of their detection performance. This review attempts to provide a comprehensive information on the ePADs including a general aspect of ePADs and recent development of ePADs by highlighting selected publication. We mainly focus on the fabrication of ePADs, enhancement strategies of nanomaterials and potential applications of ePADs in the fields of environmental monitoring, food safety management and disease diagnosis. Based on the limitations and challenges associated with the development of ePADs, the future perspectives of this research field are proposed.
TL;DR: In this paper , a novel triangular solar air collector assisted air source heat pump (TSAHP) for building heating is proposed, and three working modes including preheating, series and parallel modes are illustrated.
TL;DR: In this paper , a total of 768 metagenome assembled genome (MAGs) were retrieved from samples collected in the Site-F cold seep field in South China Sea, including the sea water closely above the invertebrate communities.
Abstract: Abstract Cold seep microbial communities are fascinating ecosystems on Earth which provide unique models for understanding the living strategies in deep-sea distinct environments. In this study, 23 metagenomes were generated from samples collected in the Site-F cold seep field in South China Sea, including the sea water closely above the invertebrate communities, the cold seep fluids, the fluids under the invertebrate communities and the sediment column around the seep vent. By binning tools, we retrieved a total of 768 metagenome assembled genome (MAGs) that were estimated to be >60% complete. Of the MAGs, 61 were estimated to be >90% complete, while an additional 105 were >80% complete. Phylogenomic analysis revealed 597 bacterial and 171 archaeal MAGs, of which nearly all were distantly related to known cultivated isolates. In the 768 MAGs, the abundant Bacteria in phylum level included Proteobacteria, Desulfobacterota, Bacteroidota, Patescibacteria and Chloroflexota, while the abundant Archaea included Asgardarchaeota, Thermoplasmatota, and Thermoproteota. These results provide a dataset available for further interrogation of deep-sea microbial ecology.