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Hua Zhang

Bio: Hua Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Graphene. The author has an hindex of 163, co-authored 1503 publications receiving 116769 citations. Previous affiliations of Hua Zhang include Shenzhen University & Zhengzhou University.


Papers
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Journal ArticleDOI
28 Oct 2011-PLOS ONE
TL;DR: Through vaccination by three doses of HB and two-dose of HBIG, majority of the infants achieved a protective level of anti-HBs at 7 months of age, and factors including gender, birth weight, gestation weeks, the rates of maternal HBeAg-positive, and detectable HBV DNA did not contribute to the non- or low-response to HB vaccination.
Abstract: Background Despite the use of hepatitis B (HB) vaccine and hepatitis B immunoglobulin (HBIG), a portion of infants are still non- or low-responders, or even immunoprophylaxis failure. We aimed to determine the immune response in the infants from the mothers being positive for hepatitis B surface antigen (HBsAg), by which the infants received three doses of HB vaccine in combination with two-dose 200 IU HBIG injections. Methods In this retrospective study, 621 infants from HBsAg-positive mothers in Beijing YouAn Hospital between January 2008 and December 2009 were included. All the infants were given three doses of 10 µg HB vaccine (at 0, 1 and 6 months of age) and two-dose of 200 IU HBIG (at birth and in 2 weeks of age). Serum HBsAg and antibody to HBsAg (anti-HBs) in all the infants were determined at 7 months of age. Results Of the 621 infants, 2.9% were immunoprophylaxis failure (positive for HBsAg), 1.4% were non-responders (anti-HBs undetectable), 95.7% were responders. The 594 responders could be categorized into three subsets, 22 were 10 to 99 IU/L for anti-HBs levels, 191 were 100 to 999 IU/L, and 381 were ≥1000 IU/L. The immunoprophylaxis failure rate was at 0% and 5.2% for the infants of HBeAg-negative and HBeAg-positive mothers(P<0.001). Infants from mothers with detectable HBV DNA had higher incidence of immunoprophylaxis failure than those of mothers without detectable HBV DNA (P = 0.002). The factors including gender, birth weight, gestation weeks, the rates of maternal HBeAg-positive, and detectable HBV DNA did not contribute to the no response to HB vaccination. Conclusions Through vaccination by three doses of HB and two-dose of HBIG, majority of the infants (95.7%) achieved a protective level of anti-HBs at 7 months of age. Maternal HBeAg-positive and HBV DNA detectable were associated with the immunoprophylaxis failure, but not contribute to the non- or low-response to HB vaccination.

29 citations

Journal ArticleDOI
01 Mar 2019-Carbon
TL;DR: In this article, a heating-assisted spray method was used to change the smooth surface and close-packed layered structure of reduced graphene oxide films (rGOFs) to rough surface and porous structure, which can be used for oil sorption, supercapacitors, and thermally/electrically conductive films.

29 citations

Journal ArticleDOI
TL;DR: In this paper, a pre-stretching process was carried out at 250°C to improve the microstructure of an AZ31 alloy to investigate its effects on micro-structure and properties.

29 citations

Journal ArticleDOI
TL;DR: In this article, a flexible and stretchable white-light-emitting double network composite hydrogels were prepared using vinyl-modified yttrium aluminum garnet phosphors (YAG:Ce-VTES) as crosslinkers and photoluminescent centers.
Abstract: White-light-emitting materials have attracted great research interest for applications in lighting, flexible display devices and biosensors. Traditional inorganic white-light-emitting materials are hard and brittle, making them difficult to apply in the field of flexible display devices. In this study, flexible and stretchable white-light-emitting double network composite hydrogels were prepared using vinyl-modified Ce-doped yttrium aluminum garnet phosphors (YAG:Ce–VTES) as crosslinkers and photoluminescent centers. The hydrogel is composed of an interpenetrating polyacrylamide (PAAm) network crosslinked by YAG:Ce–VTES and an ion-crosslinked calcium alginate network. The alginate/PAAm double network hydrogels show good stretchability and toughness, with a fracture elongation up to 600% and a compression strength up to 3.6 MPa. Moreover, white-light-emitting flexible display devices have been illuminated using a blue backlight with high luminous efficiency, optical stability and low cost. This strategy provides white-light-emitting hydrogels with good mechanical properties and lays a foundation for applications of flexible lighting and display devices.

29 citations

Journal ArticleDOI
TL;DR: The results indicate that soil serve as a catalyst in promoting oxidation of Sb(III) even under anaerobic conditions, and this can in return influence the adsorption and transported Sb.

29 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: This work reviews the historical development of Transition metal dichalcogenides, methods for preparing atomically thin layers, their electronic and optical properties, and prospects for future advances in electronics and optoelectronics.
Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.

13,348 citations