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Hua Zhang

Bio: Hua Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Graphene. The author has an hindex of 163, co-authored 1503 publications receiving 116769 citations. Previous affiliations of Hua Zhang include Shenzhen University & Zhengzhou University.


Papers
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Journal ArticleDOI
Yao Lu1, Ge Song1, Bing He1, Hua Zhang1, Xueqing Wang1, Demin Zhou1, Wenbing Dai1, Qiang Zhang1 
TL;DR: This study improves the synthesis of multifunctional nCOP and proposes a powerful photodynamic therapy with high specificity to overcome the resistance of hypoxic tumors.

25 citations

Journal ArticleDOI
29 Jan 2018-Analyst
TL;DR: The as-proposed UCNP-based FRET sensing platform has reasonable selectivity which is successfully employed to monitor caspase-3 activity in drug-induced apoptosis of HeLa cells.
Abstract: We report a new fluorescence resonance energy transfer (FRET) sensing platform for the sensitive detection of caspase-3 activity in vitro and in cells using NaGdF4:Yb3+,Er3+@NaGdF4 upconversion nanoparticles (UCNPs) as the energy donor and Rhodamine B (RB) as the energy acceptor. The phosphorylated RB-modified peptide containing a caspase-3 cleavage site and cell-penetrating peptide (CPP) motif (sequence, (RB)-DEVDGGS(p)GCGT(p)GRKKRRQRRRPQ) is immobilized on the UCNP surface via the strong coordination interaction between Gd3+ ions with phosphate. After the cleavage of DEVD by caspase-3, the RB is released from the UCNP surface and the reduced upconversion luminescence (UCL) is recovered. Under the optimum conditions, the recovery ratio of the UCL is linearly dependent on the caspase-3 concentration within the range of 0.01 to 1000 pg mL-1 and with a limit of detection (LOD) of 0.01 pg mL-1 (S/N = 3). In particular, the as-proposed UCNP-based FRET sensing platform has reasonable selectivity which is successfully employed to monitor caspase-3 activity in drug-induced apoptosis of HeLa cells.

25 citations

Journal ArticleDOI
Kai Guo1, Tao Zou1, Dejuan Jiang1, Cheng Tang1, Hua Zhang1 
01 Mar 2017
TL;DR: In this paper, an empirical algorithm was established to infer sea surface salinity and turbidity of the Yellow River (YR) plume using on surface reflectance products of MODIS and GOCI satellites in combination with observations from hydrographic surveys during the 2014 WSR event.
Abstract: Water Sediment Regulations (WSRs) of the Yellow River (YR) have fundamentally altered the dynamics of freshwater and sediment transport in YR estuary and might profoundly affect water quality and ecosystem of the adjacent Bohai Sea. In this study, empirical algorithms were established to infer sea surface salinity and turbidity of YR plume using on surface reflectance products of MODIS and GOCI satellites in combination with observations from hydrographic surveys during the 2014 WSR event. Inter- and intraday variability of salinity and turbidity were quantitatively assessed and correlated with external forces including river discharge, tides, Coriolis force, and wind-driven circulation. The results revealed the enhanced offshore extension of turbid plume as WSR drastically increased freshwater and sediment discharge to river mouth. During WSR event, the area of low salinity plume ( 2 , while sediment plume ( SR 645 >0.12sr −1 ) occupied a maximum area of 162 km 2 . Intraday variation observed from geostationary GOCI data clearly illustrated the dominance of tidal current on short term dispersal pattern of freshwater and sediment plume. In comparison, wind field dominated the seasonal variation in flume transport but had insignificant impact on short term river plume dynamic during WSR. Overall, this study demonstrated that the spatial and temporal dynamic of YR plume was successfully captured by satellite remote sensing, which provided an effective tool for evaluating the environmental and ecological impact of WSRs.

25 citations

Journal ArticleDOI
TL;DR: The high efficiency and selectivity of electrocatalytic CO2 reduction was attributed to the unique binding of metal complexes on G-quadruplex and electron transfer mediated by GQ nanowire to achieve efficient redox cycling of catalytic centers on the electrode.
Abstract: DNA as a medium for electron transfer has been widely used in photolytic processes but is seldom applied to dark reaction of CO2 reduction. A G-quadruplex nanowire (tsGQwire) assembled by guanine tetranucleotides was used to host several metal complexes and further to mediate electron transfer processes in the electrochemical reduction of CO2 catalyzed by these complexes. The tsGQwire modified electrode increased the Faradaic efficiency of cobalt(II) phthalocyanine (CoII Pc) 2.5-folds for CO production than bare CoII Pc electrode, with a total current density of 11.5 mA cm-2 . Comparable Faradaic efficiency of HCOOH production was achieved on tsGQwire electrode when the catalytic center was switched to a GQ targeting Ru complex. The high efficiency and selectivity of electrocatalytic CO2 reduction was attributed to the unique binding of metal complexes on G-quadruplex and electron transfer mediated by GQ nanowire to achieve efficient redox cycling of catalytic centers on the electrode.

25 citations

Journal ArticleDOI
TL;DR: In this paper, the effect of grain orientation on deformation behaviors and microstructure evolution of rolled AZ31 Mg alloy during uniaxial compression have been investigated as a function of temperature and strain rate.

25 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: This work reviews the historical development of Transition metal dichalcogenides, methods for preparing atomically thin layers, their electronic and optical properties, and prospects for future advances in electronics and optoelectronics.
Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.

13,348 citations