Hua Zhang

Bio: Hua Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Graphene. The author has an hindex of 163, co-authored 1503 publications receiving 116769 citations. Previous affiliations of Hua Zhang include Shenzhen University & Zhengzhou University.

Shape-Controlled Micro/Nanostructures of 9,10-Diphenylanthracene (DPA) and Their Application in Light-Emitting Devices

Abstract: Two novel shapes of 9,10-diphenylanthracene (DPA) micro/nanostructures: octahedron and sphere together with microrod and nanowire have been synthesized via a surfactant-assisted self-assembling process. These micro/nanostructures have been characterized by UV−vis, fluorescence spectra, X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), and transmission electron microscope (TEM). Our results indicated that the absorption and emission spectra of as-prepared particles were slightly blue-shift when the shape of DPA particles changed from octahedron to microrod and finally to nanowire. This result could be explained by the different growth directions of DPA micro/nanostructures. To study the relationship between shape and devices’ performance, the heterojunction light emitting diode (LED) devices of quartz/ITO/organic particles/n-SiC/Ti(10 nm)/Au(120 nm) have been prepared. The testing results showed that the different shapes of DPA micro/nanostructures did affect the performance of ...

Facile preparation of hydrated vanadium pentoxide nanobelts based bulky paper as flexible binder-free cathodes for high-performance lithium ion batteries

Abstract: Hydrated vanadium pentoxide (V2O5·0.44H2O, HVO) nanobelts were synthesized by a simply high-yield (e.g. up to ∼99%) hydrothermal approach. The length of these nanobelts was up to several hundred micrometers while the diameter was only ∼20 nm and the thickness was ∼10 nm. Binder-free bulky papers were prepared by using these HVO nanobelts and were tested as Li ion battery cathodes. The unique architecture of the HVO bulky paper provides hierarchical porous channels and large specific surface area, which facilitate fast ion diffusion and effectively strain relaxation upon charge-discharge cycling. The electrochemical tests revealed that the flexible HVO cathode could deliver high reversible specific capacities with ∼100% Coulombic efficiency, especially at high C rates. For example, it achieved a reversible capacity of 163 mAh g−1 at 6.8 C.

A combined "eat me/don't eat me" strategy based on extracellular vesicles for anticancer nanomedicine.

Abstract: A long-term and huge challenge in nanomedicine is the substantial uptake and rapid clearance mediated by the mononuclear phagocyte system (MPS), which enormously hinders the development of nanodrugs. Inspired by the natural merits of extracellular vesicles, we therefore developed a combined "eat me/don't eat me" strategy in an effort to achieve MPS escape and efficient drug delivery. Methodologically, cationized mannan-modified extracellular vesicles derived from DC2.4 cells were administered to saturate the MPS (eat me strategy). Then, nanocarriers fused to CD47-enriched exosomes originated from human serum were administered to evade phagocytosis by MPS (don't eat me strategy). The nanocarriers were also loaded with antitumor drugs and functionalized with a novel homing peptide to promote the tumour tissue accumulation and cancer cell uptake (eat me strategy). The concept was proven in vitro as evidenced by the reduced endocytosis of macrophages and enhanced uptake by tumour cells, whereas prolonged circulation time and increased tumour accumulation were demonstrated in vivo. Specially, the strategy induced a 123.53% increase in tumour distribution compared to conventional nanocarrier. The study both shed light on the challenge overcoming of phagocytic evasion and provided a strategy for significantly improving therapeutic outcomes, potentially permitting active drug delivery via targeted nanomedicines.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Electronics and optoelectronics of two-dimensional transition metal dichalcogenides.

Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.