H
Hua Zhong
Researcher at Rutgers University
Publications - 54
Citations - 6339
Hua Zhong is an academic researcher from Rutgers University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 17 publications receiving 6047 citations. Previous affiliations of Hua Zhong include Johns Hopkins University & Emory University.
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Journal Article
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
Hua Zhong,Angelo M. De Marzo,Erik Laughner,Michael Lim,David A Hilton,David Zagzag,Peter Buechler,William B. Isaacs,Gregg L. Semenza,Jonathan W. Simons +9 more
TL;DR: The first clinical data indicating that HIF-1alpha may play an important role in human cancer progression are provided, indicating adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality.
Journal Article
Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics
Hua Zhong,Kelly Chiles,David M. Feldser,Erik Laughner,Colleen Hanrahan,Maria Magdalena Georgescu,Jonathan W. Simons,Gregg L. Semenza +7 more
TL;DR: It is demonstrated that in human prostate cancer cells, basal-, growth factor- and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor Hif-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.
Journal ArticleDOI
Expression of hypoxia‐inducible factor 1α in brain tumors
David Zagzag,Hua Zhong,Joanne M. Scalzitti,Erik Laughner,Jonathan W. Simons,Gregg L. Semenza +5 more
TL;DR: The authors tested the hypothesis that HIF‐1 expression correlates with progression and angiogenesis in brain tumors and found no evidence that it correlates with disease progression.
Journal ArticleDOI
Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia.
Hua Zhong,Jonathan W. Simons +1 more
TL;DR: The results suggest that 28S rRNA is a reliable internal control for comparative analyses of transcription under hypoxia; GAPDH appears particularly unfavorable for this purpose either in Hypoxia or other experimental conditions that upregulate HIF-1alpha.
Journal Article
Geldanamycin Induces Degradation of Hypoxia-inducible Factor 1α Protein via the Proteosome Pathway in Prostate Cancer Cells
Nicola J. Mabjeesh,Dawn E. Post,Margaret T. Willard,Balveen Kaur,Erwin G. Van Meir,Jonathan W. Simons,Hua Zhong +6 more
TL;DR: It is shown that treatment of prostate cancer PC-3 and LNCaP cells with the benzoquinone ansamycin geldanamycin, an Hsp90-specific inhibitor, induced degradation of HIF-1alpha protein in a dose- and time-dependent manner under both normoxia and hypoxia.