Huang Xiaobo

Bio: Huang Xiaobo is an academic researcher. The author has contributed to research in topics: Conjugated system & Nucleophilic substitution. The author has an hindex of 3, co-authored 5 publications receiving 12 citations.

Synthetic method of diaryl substituted isoquinoline compound

Abstract: The invention relates to a synthetic method of a diaryl substituted isoquinoline compound. The synthetic method comprises a step of enabling a diaryl carbonyl compound to react with aryl trifluoro-borate in a solvent in the presence of a palladium catalyst, a nitrogen-containing ligand and an accelerant so as to prepare the diaryl substituted isoquinoline compound through one step. The synthetic method is simple in reaction, convenient to operate and high in yield, is a brand-new synthetic method for the diaryl substituted isoquinoline compound, provides a new synthetic route for preparing the compound, and has a good scientific research value and an industrial potential.

Water-soluble conjugated polymer of benzoselenadiazole and preparation method and application of conjugated polymer

Abstract: The invention relates to a benzoselenadiazole-based conjugated polymer used for detecting heavy metal ions or heavy metal-like ions and a preparation method and application of the conjugated polymer The polymer has good fluorescent response on certain ions and can serve as a fluorescence sensor In addition, due to the fluorescent response, the polymer can be used for establishing a molecular logic gate with different guest molecules, so that the polymer has good scientific research values and application potential

1,4-dihydropyridine derivatives as well as preparation method and application thereof

Abstract: The invention belongs to the field of organic chemical synthesis and application and relates to 1,4-dihydropyridine derivatives as well as a preparation method and an application thereof. The preparation method of the 1,4-dihydropyridine derivatives comprises the following steps: (1) preparing an initial sample of the 1,4-dihydropyridine derivatives; (2) recrystallizing the initial sample of the 1,4-dihydropyridine derivatives in different ways to obtain three different crystalline compounds I-y, I-o and I-r, wherein the step (1) comprises the following steps: (11) forming an intermediate 2 from 2,6-dimethyl-4H-pyran-4-one 1 as an initial material as well as Meldrum's acid through an addition-elimination reaction; (12) forming an intermediate 3 from the intermediate 2 and 4-dimethylaminobenzaldehyde through a condensation reaction; (13) synthesizing the initial sample of the 1,4-dihydropyridine derivatives from the intermediate 3 and ethylamine through nucleophilic substitution.

Dicyanomethylene-4H-pyran derivatives as well as preparation method and application thereof

Abstract: The invention particularly relates to dicyanomethylene-4H-pyran derivatives as well as a preparation method and an application thereof. The preparation method of the dicyanomethylene-4H-pyran derivatives comprises the following steps: (1) 2,6-dimethyl-4H-pyran-4-one 1 as a starting material is subjected to an addition-elimination reaction with malononitrile, and an intermediate 2 is obtained; (2) the intermediate 2 is subjected to an addition-elimination reaction with indolal with different alkyl chains, and the dicyanomethylene-4H-pyran derivatives are obtained. Indole structural units with different alkyl groups and dicyanomethylene-4H-pyran structural units are introduced into the field of organic solid luminescent materials, novel piezoluminescence color change materials are developed, and the derivatives play an important role in the field of photoelectricity. The provided method adopts a simple synthesis process, purification is easy, and the synthesized piezoluminescence materials are quite applicable to various fields of preparation of pressure sensors, anti-counterfeiting trademarks and the like and have good scientific research value and industrialized application potential.

Preparation method of beta-hydroxyphenyl selenide compound

Abstract: The invention relates to the technical field of synthesis of organic compounds and particularly relates to a preparation method of a beta-hydroxyphenyl selenide compound. The preparation method comprises the step of with aryl boronic acid with a structure presented by a formula (I), elemental selenium and an ethylene oxide derivative presented by a formula (II) as the raw materials, and carrying out insertion reaction on elemental selenium in a reaction solvent under the common effect of a copper catalyst, silver salt and alkali, so as to obtain the beta-hydroxyphenyl selenide compound represented by a formula (III), wherein R1 and R2 are respectively independently selected from one of H, a benzene ring, a naphthalene ring, a heterocyclic ring, a substituted benzene ring, linear alkyl, branched chain, halogen, nitryl and a cyano group.

Detection reagent for heavy metal ions and synthesis method thereof

Abstract: The invention provides a detection reagent for heavy metal ions and a synthesis method thereof, and belongs to the technical field of organic synthesis. The synthesis method of the reagent comprises the following steps: (1) dissolving o-phenylenediamine in a hydrochloric acid solution; (2) adding ethylenediaminetetraacetic acid and a hydrochloric acid solution into a three necked flask, heating and dissolving, and controlling reaction temperature; (3) slowly adding dropwise the solution obtained in the step (1) into the solution obtained in the step (2), and after the solution obtained in the step (1) is completely added dropwise into the solution obtained in the step (2), continuing reflux for reaction; and (4) naturally cooling the reaction solution at room temperature, filtering, cooling filtrate for 8 to 12h for precipitation of a colorless crystal, filtering by suction, washing a filtering cake with anhydrous ethanol and drying to obtain the target detection reagent. The reagent and lead, cadmium and copper ions can form stable complexes with strong absorption in an ultraviolet region, the stable complexes can be detected by an ultraviolet detector of a liquid chromatography, the synthesis process is simple, production is easy to realize, raw materials are easy to obtain, production cost is low, detection signals are stabile and have good reproducibility, and the detection reagent is worthy of wide application and promotion.

Preparation method for diphenyl diselenium compound

Abstract: The invention discloses a preparation method for a diphenyl diselenium compound. According to the method, an arylboronic acid compound and elemental selenium serve as reaction raw materials, an organic solvent serves as a reaction solvent, under the effect of a silver catalyst, reaction is carried out so as to obtain the diphenyl diselenium compound, the reaction temperature is 100-140 DEG C, thereaction equation is shown in the specification, wherein R is a benzene ring, a naphthalene ring, a heterocyclic ring or a substituted benzene ring. The method has the beneficial effects that the tolerance of functional groups of substrates is high, and the range of the substrates is wide; and the raw materials and the catalyst are cheap and easily available, the conditions are mild, the post-treatment is simple, the yield and purity of a product are high, and the method is suitable for large-scale industrial production.

Synthetic method of antitumor nitrogen-containing heterocyclic drug intermediates

Abstract: The invention relates to a synthetic method of isoquinolinone compounds shown by formula (III) shown in the description and acting as antitumor nitrogen-containing heterocyclic drug intermediates; the method comprises: enabling a compound of formula (I) shown in the description and a compound of formula (II) shown in the description to react in a reaction solvent in the presence of a catalyst, a nitrogen-containing ligand and an acid catalyst, and treating after reaction to obtain the compound of formula (III), wherein R1 is C1-C6 alkyl, and R2 is H, halogen, C1-C6 alkyl or C1-C6 alkoxy, or R2 and R2-substituted phenyl form naphthyl. Through the comprehensive selection and interaction of a reaction substrate, catalysts, nitrogen-containing ligands, acid catalysts, reaction solvents and the like according to the method, the substrate range is widened, and the isoquinolinone compound is acquired at high yield; more diversified intermediates are provided for novel synthesis of the compounds and the research, development and synthesis of antitumor drugs, and the compounds have good research value and application potential.

Preparation of aggregation-induced emission material with light stability

Abstract: The invention discloses a hindered amine light stabilizer with an aggregation-induced emission (AIE) performance and a synthesis method thereof The hindered amine light stabilizer is formed through steps including a step of ensuring that AIE pyrone derivative is reacted with hindered amine The formed hindered amine light stabilizer not only has excellent light stability, but also has an aggregation-induced emission performance and a piezallochromy performance