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Huanqing Yang

Bio: Huanqing Yang is an academic researcher from Max Planck Society. The author has contributed to research in topics: Medicine & Neuroscience. The author has an hindex of 1, co-authored 1 publications receiving 6 citations.

Papers
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Journal ArticleDOI
04 Mar 2021-Stress
TL;DR: There are differences in the way that female and male mice respond towards chronic social stress conditions when it comes to behavior and hormonal changes, which are partially dependent on estrous cycle stage.
Abstract: Over the years, it has become increasingly clear that males and females respond differently towards environmental stressors, highlighting the importance of including both sexes when studying the ef...

22 citations

Journal ArticleDOI
01 May 2022-Neuron
TL;DR: In this paper , the Kcnq2 gene was identified as an important downstream regulator of ketamine action in glutamatergic neurons of the ventral hippocampus, and the authors showed that adjunctive treatment with retigabine, a KCNQ activator, augments ketamine's antidepressant-like effects in mice.

17 citations

Journal ArticleDOI
TL;DR: In this paper , the role of FKBP51 in the ventromedial hypothalamus (VMH) was investigated by conditional deletion and virus-mediated overexpression of SF1-positive neurons.
Abstract: Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset of obesity. The co-chaperone FKBP51 is abundantly expressed in the VMH and was recently linked to type 2 diabetes, insulin resistance, adipogenesis, browning of white adipose tissue (WAT) and bodyweight regulation.We investigated the role of FKBP51 in the VMH by conditional deletion and virus-mediated overexpression of FKBP51 in SF1-positive neurons. Baseline and high fat diet (HFD)-induced metabolic- and stress-related phenotypes in male and female mice were obtained.In contrast to previously reported robust phenotypes of FKBP51 manipulation in the entire mediobasal hypothalamus (MBH), selective deletion or overexpression of FKBP51 in the VMH resulted in only a moderate alteration of HFD-induced bodyweight gain and body composition, independent of sex.Overall, this study shows that animals lacking and overexpressing Fkbp5 in Sf1-expressing cells within the VMH display only a mild metabolic phenotype compared to an MBH-wide manipulation of this gene, suggesting that FKBP51 in SF1 neurons within this hypothalamic nucleus plays a subsidiary role in controlling whole-body metabolism.

2 citations

Journal ArticleDOI
17 Apr 2023-Stress
TL;DR: In this article , the role of mineralocorticoid receptors (MRs) in stress-related psychiatric disorders was reviewed, starting with an overview of the physiological structure, ligand binding, and expression of MR, and further summarizing its role in the brain, its relevance to psychiatric disorders, and related rodent studies.
Abstract: Stress is a normal response to situational pressures or demands. Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis and leads to the release of corticosteroids, which act in the brain via two distinct receptors: mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Persistent HPA axis overactivation or dysregulation can disrupt an individual's homeostasis, thereby contributing to an increased risk for mental illness. On the other hand, successful coping with stressful events involves adaptive and cognitive processes in the brain that render individuals more resilient to similar stressors in the future. Here we review the role of the MR in these processes, starting with an overview of the physiological structure, ligand binding, and expression of MR, and further summarizing its role in the brain, its relevance to psychiatric disorders, and related rodent studies. Given the central role of MR in cognitive and emotional functioning, and its importance as a target for promoting resilience, future research should investigate how MR modulation can be used to alleviate disturbances in emotion and behavior, as well as cognitive impairment, in patients with stress-related psychiatric disorders.
Journal ArticleDOI
TL;DR: In this article , the authors demonstrate that FKBP5 affects cognitive and emotional behavior, brain structure, and brain region-specific gene expression profiles in a highly cell-type and sex-specific manner.
Abstract: Significance The FKBP5 gene is a key genetic risk factor for stress-related disorders. The highly divergent symptomology of psychiatric disorders highlights that genetic risk factors like FKBP5 do not simply affect stress-coping mechanisms in a unilateral manner. Rather, we here demonstrate that FKBP5 affects cognitive and emotional behavior, brain structure, and brain region-specific gene expression profiles in a highly cell-type and sex-specific manner. Our results underline that labelling a stress—sensitive factor as FKBP5 as “risk factor” is too simplistic, as loss of FKBP5 can have opposite effects on brain and behavior, dependent on which cell type and sex the loss is taking place. The results are of high importance for the development of targeted intervention strategies for psychiatric disorders.

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Journal ArticleDOI
TL;DR: A phase 2 clinical trial of arketamine in treatment-resistant patients with major depressive disorder (MDD) and other psychiatric disorders, such as bipolar disorder and post-traumatic stress disorder, is underway as mentioned in this paper .

32 citations

Journal ArticleDOI
TL;DR: In this article, a review summarizes the findings and analyses their methodology and proposes adherence to the Research Domain Criteria and the STRANGE framework to minimize experimental bias and increase data purview.
Abstract: Depression affects around 320 million people worldwide. Growing evidence proposes the immune system to be the core interface between psychosocial stress and the neurobiological and behavioural features of depression. Many studies have identified purinergic signalling via the P2X7 receptor (P2X7R) to be of great importance in depression genesis yet only a few have evaluated P2X7R antagonists in chronic stress-based depression models. This review summarizes their findings and analyses their methodology. The four available studies used three to nine weeks of unpredictable, chronic mild stress or unpredictable, chronic stress in male mice or rats. Stress paradigm composition varied moderately, with stimuli being primarily psychophysical rather than psychosocial. Behavioural testing was performed during or after the last week of stress application and resulted in depressive-like behaviours, immune changes (NLRP3 assembly, interleukin-1β level increase, microglia activation) and neuroplasticity impairment. During the second half of each stress paradigm, a P2X7R antagonist (Brilliant Blue G, A-438079, A-804598) was applied. Studies differed with regard to antagonist dosage and application timing. Nonetheless, all treatments attenuated the stress-induced neurobiological changes and depressive-like behaviours. The evidence at hand underpins the importance of P2X7R signalling in chronic stress and depression. However, improvements in study planning and reporting are necessary to minimize experimental bias and increase data purview. To achieve this, we propose adherence to the Research Domain Criteria and the STRANGE framework.

16 citations

Journal ArticleDOI
TL;DR: In this article, the role of Shati/Nat8l in stress sensitivity in mice was investigated and it was found that Shati and N8l levels in the dorsal striatum were increased in stress-susceptible mice but not in resilient mice exposed to repeated social defeat stress (RSDS).

13 citations

Journal ArticleDOI
01 Jul 2022-Neuron
TL;DR: Lopez et al. as mentioned in this paper showed that the potassium voltage-gated channel subfamily Q member 2 (KCNQ2) is essential for the sustained antidepressant-like effects of ketamine in glutamatergic neurons of the ventral hippocampus.

11 citations

Journal ArticleDOI
TL;DR: In this paper , behavioral, physiological, and neuroendocrine profiles of mice were analyzed in three separate phases: before, during, and following chronic social defeat stress. And they found that behavioral coping strategies used during the initial social stress encounter better predict which mice will eventually become resilient or susceptible, indicating early differences in coping mechanisms used between the two groups.

11 citations