Author
Huayan Nong
Bio: Huayan Nong is an academic researcher. The author has contributed to research in topics: Nanoprobe & Medical imaging. The author has co-authored 1 publications.
Papers
More filters
TL;DR: In this paper, a new manganese and dysprosium codoped carbon quantum dots (Mn,Dy-CQDs) with a mean diameter of 1.77 nm was synthesized for fluorescence imaging, T1/T2-weighted magnetic resonance imaging (T 1/T 2 -weighted MRI), and x-ray computed tomography (CT) imaging using a simple one-step hydrothermal approach.
Abstract: It has been challenging to integrate various medical imaging modalities into an ultra-small nanoparticle with good biocompatibility to build highly efficient multimodal imaging nanoprobes. A new manganese and dysprosium codoped carbon quantum dots (Mn,Dy-CQDs) with a mean diameter of 1.77 nm was synthesized for fluorescence imaging,T1/T2-weighted magnetic resonance imaging (T1/T2-weighted MRI), and x-ray computed tomography (CT) imaging using a simple one-step hydrothermal approach. The obtained Mn,Dy-CQDs showed good water solubility, long-term stability, strong stable fluorescence property (fluorescence quantum yield of 31.62%), and excellent biocompatibility. The cell imaging verified that the Mn,Dy-CQDs have high efficiency of fluorescence imaging. The Mn,Dy-CQDs, on the other hand, had a superior x-ray absorption performance (47.344 HU l g-1), a higher longitudinal relaxivity (r1 = 7.47 mM-1s-1), a higher transverse relaxivity (r2 = 42.686 mM-1s-1).In vitroT1/T2-weighted MRI and CT imaging showed that Mn,Dy-CQDs can produce a strong contrast enhancement impact. To summarise, the Mn,Dy-CQDs may be used as aT1/T2-weighted MRI/CT/fluorescent quadri-modal imaging nanoprobe, indicating that they have a lot of uses in biomedical multimode imaging and clinics.
2 citations
Cited by
More filters
TL;DR: A review article summarizes the main features of photodynamic therapy and carbon-based quantum dots with an emphasis on used photosensitizer drugs and methods for synthesis of carbon dots as discussed by the authors .
8 citations
TL;DR: In this article , the terbium-doped CDs (Tb-CDs) were examined as a novel contrast agent for computed tomography and a detailed physicochemical analysis revealed that the prepared CDs have small sizes (∼2-3 nm), contain relatively high Terbium concentration ( ∼13.3 wt%), and exhibit excellent aqueous colloidal stability.
Abstract: Metal-doped carbon dots have attracted considerable attention in nanomedicine over the last decade owing to their high biocompatibility and great potential for bioimaging, photothermal therapy, and photodynamic therapy. In this study, we prepared, and for the first time, examined terbium-doped CDs (Tb-CDs) as a novel contrast agent for computed tomography. A detailed physicochemical analysis revealed that the prepared Tb-CDs have small sizes (∼2–3 nm), contain relatively high terbium concentration (∼13.3 wt%), and exhibit excellent aqueous colloidal stability. Furthermore, preliminary cell viability and CT measurements suggested that Tb-CDs exhibit negligible cytotoxicity toward L-929 cells and demonstrate high X-ray absorption performance (∼48.2 ± 3.9 HU L g−1). Based on these findings, the prepared Tb-CDs could serve as a promising contrast agent for efficient X-ray attenuation.