H
Hugo van Ingen
Researcher at Utrecht University
Publications - 44
Citations - 2104
Hugo van Ingen is an academic researcher from Utrecht University. The author has contributed to research in topics: Nucleosome & Histone. The author has an hindex of 18, co-authored 41 publications receiving 1816 citations. Previous affiliations of Hugo van Ingen include Radboud University Nijmegen & Leiden University.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
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Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR
Hidenori Kato,Hugo van Ingen,Bing-Rui Zhou,Hanqiao Feng,Michael Bustin,Lewis E. Kay,Yawen Bai +6 more
TL;DR: The architecture of the HMGN2-nucleosome complex determined by a combination of methyl-transverse relaxation optimized nuclear magnetic resonance spectroscopy (methyl-TROSY) and mutational analysis is reported, providing insight into how HMGNs regulate chromatin structure through interfering with the binding of linker histone H1 to the nucleosome.
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Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.
Hugo van Ingen,Frederik M. A. van Schaik,Hans Wienk,Joost Ballering,Holger Rehmann,Annemarie C. Dechesne,John A.W. Kruijzer,Rob M. J. Liskamp,H. Th. Marc Timmers,Rolf Boelens +9 more
TL;DR: The structural basis of binding affinity, methylation-state specificity, and crosstalk with asymmetric dimethylation of R2 is revealed and a H3R2/K4 "methyl-methyl" switch in the histone code dynamically regulates TFIID-promoter association.
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Nucleosomal DNA Binding Drives the Recognition of H3K36-Methylated Nucleosomes by the Psip1-Pwwp Domain.
Rick van Nuland,Frederik M. A. van Schaik,Marieke Simonis,Sebastiaan van Heesch,Edwin Cuppen,Rolf Boelens,H. T. Marc Timmers,Hugo van Ingen +7 more
TL;DR: Concerted binding to the methylated histone tail and nucleosomal DNA underlies the high- affinity, specific recognition of H3K36me nucleosomes by the PSIP1-PWWP domain.
Journal ArticleDOI
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
TL;DR: Crosslinking mass spectrometry (XL-MS) is used to chart the protein-protein interactions in intact human nuclei, and the analysis of crosslinks carrying posttranslational modifications allowed us to extract how specific modifications influence nucleosome interactions.