H
Hui C. Tsou
Researcher at Columbia University
Publications - 20
Citations - 3273
Hui C. Tsou is an academic researcher from Columbia University. The author has contributed to research in topics: PTEN & Cowden syndrome. The author has an hindex of 15, co-authored 20 publications receiving 3173 citations. Previous affiliations of Hui C. Tsou include Tufts Medical Center & University of Massachusetts Medical School.
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Journal ArticleDOI
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
Danny Liaw,Deborah J. Marsh,Jing Li,Patricia L. M. Dahia,Steven I. Wang,Z. Zheng,Shikha Bose,K. M. Call,Hui C. Tsou,Monica Peacocke,Charis Eng,Ramon Parsons +11 more
TL;DR: Mutational analysis of PTEN in CD kindreds has identified germline mutations that are predicted to disrupt the protein tyrosine/dual-specificity phosphatase domain of this gene, and implies that PTEN may play a role in organizing the relationship of different cell types within an organ during development.
Journal ArticleDOI
Alopecia Universalis Associated with a Mutation in the Human hairless Gene
Wasim Ahmad,Muhammad Faiyaz ul Haque,Valeria Brancolini,Hui C. Tsou,Sayed ul Haque,HaMut Lam,Vincent M. Aita,Jason E. Owen,Michelle deBlaquiere,Jorge Frank,P. B. Cserhalmi-Friedman,Andrew Leask,John A. McGrath,Monica Peacocke,Mahmud Ahmad,Jurg Ott,Angela M. Christiano +16 more
TL;DR: A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19 as discussed by the authors ).
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Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer.
TL;DR: It is shown that women with CS have a spectrum of exuberant benign and malignant breast pathology, whereas the most frequent breast malignancy is ductal carcinoma.
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The Role of MMAC1 Mutations in Early-Onset Breast Cancer: Causative in Association with Cowden Syndrome and Excluded in BRCA1-Negative Cases
Hui C. Tsou,David H. F. Teng,Xiao Li Ping,Valeria Brancolini,Thaylon Davis,Rong Hu,Xiao Xun Xie,Alexandra C. Gruener,Carolina A. Schrager,Angela M. Christiano,Charis Eng,Peter A. Steck,Jurg Ott,Sean V. Tavtigian,Monica Peacocke +14 more
TL;DR: It is demonstrated that MMAC1 mutations are associated with CS and breast cancer, and it is shown that certain families and individuals with CS do not have mutations in the coding sequence ofMMAC1.
Journal ArticleDOI
PTEN/MMAC1 mutations in hepatocellular carcinomas
Ya Juan Yao,Xiao Li Ping,Hong Zhang,Fei Fei Chen,Patricia K. Lee,Habibul Ahsan,Chien-Jen Chen,Po-Huang Lee,Monica Peacocke,Regina M. Santella,Hui C. Tsou +10 more
TL;DR: Sequence analysis of 96 hepatocellular carcinoma samples from Taiwan provided the first evidence that the PTEN/MMAC1 gene is mutated in a subset of HCC samples, with missense mutations in exon 5 and exon 7.