H
Hui-Chun Cheng
Researcher at University of Texas Southwestern Medical Center
Publications - 11
Citations - 2687
Hui-Chun Cheng is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Wiskott–Aldrich syndrome protein & Actin cytoskeleton. The author has an hindex of 10, co-authored 11 publications receiving 2109 citations. Previous affiliations of Hui-Chun Cheng include National Tsing Hua University & University of California, San Francisco.
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Journal ArticleDOI
Phase transitions in the assembly of multivalent signalling proteins
Pilong Li,Sudeep Banjade,Hui-Chun Cheng,Soyeon Kim,Baoyu Chen,Liang Guo,Marc C. Llaguno,Javoris Hollingsworth,David S. King,Salman F. Banani,Paul S. Russo,Qiu-Xing Jiang,B. Tracy Nixon,Michael K. Rosen +13 more
TL;DR: Interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produce sharp liquid–liquid-demixing phase separations, generating micrometre-sized liquid droplets in aqueous solution.
Journal ArticleDOI
Hierarchical regulation of WASP/WAVE proteins.
Shae B. Padrick,Hui-Chun Cheng,Ayman M. Ismail,Sanjay C. Panchal,Lynda K. Doolittle,Soyeon Kim,Brian M. Skehan,Junko Umetani,Chad A. Brautigam,John M. Leong,Michael K. Rosen +10 more
TL;DR: Dimmerization increases the affinity of active WASP species for Arp2/3 complex by up to 180-fold, greatly enhancing actin assembly by this system, and explains a large and apparently disparate set of observations under a common mechanistic framework.
Journal ArticleDOI
Arp2/3-independent assembly of actin by Vibrio type III effector VopL
Amy D. B. Liverman,Hui-Chun Cheng,Jennifer E. Trosky,Daisy W. Leung,Melanie L. Yarbrough,Dara Burdette,Michael K. Rosen,Kim Orth +7 more
TL;DR: Vibrio VopL is predicted to be a bacterial virulence factor that disrupts actin homeostasis during an enteric infection of the host.
Journal ArticleDOI
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.
Didier F. Vingadassalom,Arunas Kazlauskas,Brian M. Skehan,Hui-Chun Cheng,Loranne Magoun,Douglas Robbins,Michael K. Rosen,Kalle Saksela,John M. Leong +8 more
TL;DR: Enterohemorrhagic E. coli translocates 2 effectors that bind to distinct domains of a common host factor to promote the formation of a complex that triggers robust actin assembly at the plasma membrane.
Journal ArticleDOI
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
TL;DR: It is shown that EspFU binds to the autoinhibitory GTPase binding domain (GBD) in WASP proteins and displaces it from the activity-bearing VCA domain (for verprolin homology, central hydrophobic and acidic regions) in autoinhibited WASP.