Synthesis of biodegradable polymers from renewable resources

Wound Healing Bionanocomposites Based on Castor Oil Polymeric Films Reinforced with Chitosan-Modified ZnO Nanoparticles.

Keratin based bioplastic film from chicken feathers and its characterization.

Synthesis of Biobased Polyurethane from Oleic and Ricinoleic Acids as the Renewable Resources via the AB-Type Self-Condensation Approach

A new series of soybean-oil-based elastomers poly(epoxidized soybean oil-co-decamethylene diamine) (PESD) was synthesized by ring-opening polymerization from epoxidized soybean oil (ESO) and decamethylene diamine (DDA) in different molar ratios. The effect of the molar ratio on the structure and properties of PESD was identified by various methods. According to the results of Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR) and thermogravimetry (TGA), the glycerol center of ESO was broken by ammonolysis as expected in the process of polymerization, which resulted in un-cross-linked elastomers with low glass transition temperatures (Tg) ranging from −30 to −17 °C. PESD-3 (molar ratio of DDA to ESO is 2:1) was found to have the highest molecular weight and was most suitable for further processing. Then, PESD-3 was successfully cross-linked through succinic anhydride by a general rubber processing method to obtain a cross-linked bioelastomer. The mechanism of chain growth, ...

Synthesis and characterization of novel soybean-oil-based elastomers with favorable processability and tunable properties

Biodegradable foam plastics based on castor oil.

The prodrug approach has emerged as a promising solution to combat bacterial resistance and enhance treatment efficacy against bacterial infections. Here, we report an adenosine triphosphate (ATP)-activated prodrug system for on-demand treatment of bacterial infection. The prodrug system benefits from the synergistic action of zeolitic imidazolate framework-8 and polyacrylamide hydrogel microsphere, which simultaneously transports indole-3-acetic acid and horseradish peroxidase in a single carrier while preventing the premature activation of indole-3-acetic acid. The ATP-responsive characteristic of zeolitic imidazolate framework-8 allows the prodrug system to be activated by the ATP secreted by bacteria to generate reactive oxygen species (ROS), displaying exceptional broad-spectrum antimicrobial ability. Upon disruption of the bacterial membrane by ROS, the leaked intracellular ATP from dead bacteria can accelerate the activation of the prodrug system to further enhance antibacterial efficiency. In vivo experiments in a mouse model demonstrates the applicability of the prodrug system for wound disinfection with minimal side effects. 

/pdf/adenosine-triphosphate-activated-prodrug-system-for-on-2eh34pas.pdf

Hui Wen Chen

Papers

Biodegradable foam plastics based on castor oil.

Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Hydrogel Microreactor Integrated Double Cascade Reactions for Synergistic Bacterial Inactivation and Wound Disinfection