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Huijie Gao
Researcher at Shandong University
Publications - 16
Citations - 408
Huijie Gao is an academic researcher from Shandong University. The author has contributed to research in topics: Integrin & Metastasis. The author has an hindex of 10, co-authored 14 publications receiving 320 citations. Previous affiliations of Huijie Gao include Chinese Ministry of Education.
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Journal ArticleDOI
The β6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer
Song Liu,Jian Wang,Jian Wang,Weibo Niu,Enyu Liu,Jiayong Wang,Cheng Peng,Pengfei Lin,Ben Wang,Ben Wang,Abdul Qadir Khan,Huijie Gao,Huijie Gao,Benjia Liang,Benjia Liang,Muhammad Shahbaz,Jun Niu +16 more
TL;DR: Over-expression of β6-integrin protected SW480 and HT-29 colon cancer cells from 5-FU-induced growth inhibition and apoptosis, which was accompanied by changes in cytochrome C released from the mitochondria and activity of caspases-3 and caspase-9.
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Comparison of the BISAP scores for predicting the severity of acute pancreatitis in Chinese patients according to the latest Atlanta classification
Jia Zhang,Muhammad Shahbaz,Ruliang Fang,Benjia Liang,Chao Gao,Huijie Gao,Muhammad Ijaz,Cheng Peng,Ben Wang,Zhengchuan Niu,Jun Niu +10 more
TL;DR: BISAP, the Acute Physiology and Chronic Health Evaluation (APACHE) II and Ranson scoring systems are compared in predicting the severity, pancreatic necrosis and mortality of acute pancreatitis using the latest 2012 Atlanta classification in a tertiary care center in China.
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Integrinβ6-Targeted Immunoliposomes Mediate Tumor-Specific Drug Delivery and Enhance Therapeutic Efficacy in Colon Carcinoma
Benjia Liang,Muhammad Shahbaz,Yang Wang,Huijie Gao,Huijie Gao,Ruliang Fang,Zhengchuan Niu,Zhengchuan Niu,Song Liu,Song Liu,Ben Wang,Ben Wang,Qi Sun,Qi Sun,Weibo Niu,Enyu Liu,Jiayong Wang,Jun Niu +17 more
TL;DR: In vivo, the therapeutic activity of ITGB6-targeted immunoliposomes+5-FU was significantly superior, resulting in 25% to 35% reduction of tumor weight compared with 5-FU or liposomes+, and thus offer the potential of a novel and promising anticancer strategy for clinical therapy.
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Interleukin-8 promotes cell migration through integrin αvβ6 upregulation in colorectal cancer.
Qi Sun,Qi Sun,Fengkai Sun,Ben Wang,Ben Wang,Song Liu,Weibo Niu,Enyu Liu,Cheng Peng,Jiayong Wang,Huijie Gao,Huijie Gao,Benjia Liang,Benjia Liang,Zhengchuan Niu,Zhengchuan Niu,Xueqing Zou,Xueqing Zou,Jun Niu +18 more
TL;DR: IL-8 enhances the migration of CRC cells by increasing αvβ6 integrin expression through the ERK/Ets-1 pathway, and Targeting integrin αv β6 in IL-8 expressing tumors might be a potential therapeutic strategy for CRC patients.
Journal ArticleDOI
β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway.
Huijie Gao,Huijie Gao,Cheng Peng,Cheng Peng,Benjia Liang,Benjia Liang,Muhammad Shahbaz,Muhammad Shahbaz,Song Liu,Ben Wang,Ben Wang,Qi Sun,Qi Sun,Zhengchuan Niu,Zhengchuan Niu,Weibo Niu,Enyu Liu,Jiayong Wang,Pengfei Lin,Jian Wang,Jun Niu +20 more
TL;DR: This study demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells and that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of M MP genes.