Author
Hulin Fang
Bio: Hulin Fang is an academic researcher from National Taiwan Normal University. The author has contributed to research in topics: One-pot synthesis & Michael reaction. The author has an hindex of 5, co-authored 8 publications receiving 187 citations.
Papers
More filters
TL;DR: An easy and efficient method to generate indolyl nitroalkane 5 and pyrrolyl n-alkane 7 in high yields using β-nitrostyrene and indole/pyrrole at room temperature in the presence of catalytic amount of iodine is reported in this article.
105 citations
TL;DR: In this article, a variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions and the combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanones and tetrahedropyridine derivatives.
49 citations
TL;DR: The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one via a three-component reaction of aldehydes, anilines, and 1-acetylcyclohexene in the presence of iodine in a one-pot reaction at room temperature is described.
Abstract: The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one (4) via a three-component reaction of aldehydes (1), anilines (2), and 1-acetylcyclohexene (3) in the presence of iodine in a one-pot reaction at room temperature is described. The short reaction time, easy workup, excellent yield, and mild reaction conditions make this novel annulation strategy both practical and attractive.
31 citations
TL;DR: In this article, the one-pot synthesis of malononitrile derivatives was reported in moderate to high yields by the reaction of ylidenemalononitriles 3, prepared in situ from carbonyl compounds 1 and malononiitrile 2 in the presence of ammonium acetate in aqueous solution at 50-60°C, with RI 5/Et3B in a water-diethyl ether biphase medium under an atmosphere of room temperature.
11 citations
TL;DR: The reactions of 2-hydroxyacetophenones as the enolizable ketone component, aromatic aldehydes, and aniline provide flavanones as sole products, and not the expected β-aminocarbonyl compounds.
Abstract: The reactions of 2-hydroxyacetophenones as the enolizable ketone component, aromatic aldehydes, and aniline provide flavanones as sole products, and not the expected β-aminocarbonyl compounds.
6 citations
Cited by
More filters
TL;DR: This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.
Abstract: 140 years ago Adolf von Baeyer proposed the structure of a heteroaromatic compound which revolutionized organic and medical chemistry: indole. After more than a century, indole itself and the complexity of naturally occurring indole derivatives continue to inspire and influence developments in synthetic chemistry. In particular, the ubiquitous presence of indole rings in pharmaceuticals, agrochemicals, and functional materials are testament to the ever increasing interest in the design of mild and efficient synthetic routes to functionalized indole derivatives. This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.
1,141 citations
TL;DR: This Perspective highlights advances made by the laboratory since the inception of the photoredox/Ni cross-coupling of benzyltrifluoroborates with aryl bromides and the net C–H functionalization of the radical partner in an effort to improve atom economy.
Abstract: Photoredox catalysis has experienced a revitalized interest from the synthesis community during the past decade. For example, photoredox/Ni dual catalysis protocols have been developed to overcome several inherent limitations of palladium-catalyzed cross-couplings by invoking a single-electron transmetalation pathway. This Perspective highlights advances made by our laboratory since the inception of the photoredox/Ni cross-coupling of benzyltrifluoroborates with aryl bromides. In addition to broadening the scope of trifluoroborate coupling partners, research using readily oxidized hypervalent silicates as radical precursors that demonstrate functional group compatibility is highlighted. The pursuit of electrophilic coupling partners beyond (hetero)aryl bromides has also led to the incorporation of several new classes of C(sp2)-hybridized substrates into light-mediated cross-coupling. Advances to expand the radical toolbox by utilizing feedstock chemicals (e.g., aldehydes) to access radicals that were prev...
394 citations
TL;DR: In this paper, the Fortschritte hinsichtlich der selektiven katalytischen Funktionalisierung von Indolen (durch C-C-Kupplung) aus den vergangenen vier Jahre zusammen.
Abstract: Vor 140 Jahren schlug Adolf von Baeyer die Struktur fur eine heteroaromatische Verbindung vor, die die organische und medizinische Chemie nachhaltig veranderte: Indol. Nach mehr als einem Jahrhundert beeinflussen Indol selbst, ebenso wie naturliche Indolderivate, weitgehend die Entwicklung in der Synthesechemie. Vor allem die allgegenwartige Prasenz des Indolrings in pharmazeutischen und agrochemischen Verbindungen sowie seine Verwendung in der Materialchemie sind ausschlaggebend fur das anhaltende Interesse an der Entwicklung von neuen milden und effizienten Synthesestrategien fur funktionalisierte Indolderivate. Dieser Aufsatz fasst die Fortschritte hinsichtlich der selektiven katalytischen Funktionalisierung von Indolen (durch C-C-Kupplung) aus den vergangenen vier Jahre zusammen.
291 citations
TL;DR: In this article, the authors put MOFs into perspective with respect to their homogeneous counterparts and more conventional heterogeneous catalysts to show their advantages and limitations, and illustrate using selected examples what the potential advantages of MOF catalysts could be, and how they may outperform the potential of other solid catalysts.
Abstract: Metal–organic frameworks have recently attracted attention as heterogeneous catalysts due to their high content of metal centres and large surface area and pore volume, along with their impressive topological richness. Therefore, many studies describing the use of MOFs as heterogeneous Lewis acid catalysts have been published. In this regard, these efforts have been directed towards probing the catalytic activity. Further information is required in terms of kinetic parameters and comparison of performance with their homogeneous counterparts, or other conventional heterogeneous catalysts. Here we have attempted to put MOFs into perspective with respect to their homogeneous counterparts and more conventional heterogeneous catalysts to show their advantages and limitations. We have exemplified a number of reactions reported in the literature wherein MOFs have been used as catalysts, and we have carried them out using homogeneous counterparts, i.e. benzoates and acetates, and other well defined conventional solid catalysts. The activities and selectivities of the catalysts are compared and then put into perspective on the basis of kinetic parameters, such as turnover numbers and turnover frequencies. Additionally, we illustrate using selected examples what the potential advantages of MOF catalysts could be, and how they may outperform the potential of other solid catalysts.
281 citations
257 citations