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Hung Manh Do

Bio: Hung Manh Do is an academic researcher from Vietnam Academy of Science and Technology. The author has contributed to research in topics: Magnetization & Magnetic nanoparticles. The author has an hindex of 6, co-authored 15 publications receiving 129 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors synthesize Fe 3 O 4 nanoparticles with high saturation magnetization by thermal decomposition method using an inexpensive surfactant/reductant with short reaction time.

43 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present facile and non-toxic synthetic approaches for size-controllable preparations of magnetite nanoparticles, which are appropriate for biomedical applications, namely (i) co-precipitation; (ii) reduction-preCipitation and (iii) oxidation precipitation.
Abstract: Magnetite nanoparticles are one of the most important materials that are widely used in both medically diagnostic and therapeutic research. In this paper, we present some facile and non-toxic synthetic approaches for size-controllable preparations of magnetite nanoparticles, which are appropriate for biomedical applications, namely (i) co-precipitation; (ii) reduction‐precipitation and (iii) oxidation‐precipitation. Magnetic characterizations of the obtained nanoparticles have been studied and discussed. The oxidation precipitation route was chosen for investigation of the dependence of kinetic driven activation energy and that of coercive force on particle size (and temperature) during the course of the reaction. The structural‐magnetic behavior was also correlated. Being solvent and surfactant-free, these methods are advantageous for synthesis and further functionalization towards biomedical applications.

24 citations

Journal ArticleDOI
TL;DR: In this article, the diameter and the length of a TiO2 nanotube were estimated by using scanning electron microscopy and it was shown that the largest diameter and longest length of about 80nm and 20μm, respectively, were obtained for the sample anodized in a solution containing 0.4% of NH4F, under a voltage of 48 V.
Abstract: Perpendicularly self-aligned TiO2 nanotube samples of size of 3 × 5 cm2 were fabricated by the electrochemical anodization method using a solution containing NH4F. Influences of the technological conditions such as NH4F concentration and anodization voltage were studied. It was found that NH4F concentration in the solution and anodization voltage significantly affect the diameter and length of a TiO2 nanotube. The diameter and the length of a TiO2 nanotube were observed and estimated by using scanning electron microscopy. It has shown that the largest diameter and the longest length of about 80 nm and 20 μm, respectively, were obtained for the sample anodized in a solution containing 0.4% of NH4F, under a voltage of 48 V. Photoluminescence spectra excited by laser lights having wavelengths of 325 and 442 nm (having energies higher and lower than the band gap energy of TiO2) was recorded at room temperature for the TiO2 nanotube arrays. An abnormal luminescence result was observed. It is experimental evidence that the manufactured TiO2 nanotube array is an expected material for hydrogen splitting from water by photochemical effect under sunlight as well as for the nano solar cells.

21 citations

Journal ArticleDOI
TL;DR: In this article, the authors presented new results dealing with attempting to apply the MNP/copolymer ferrofluid for treatment of Sarcoma 180 tumor, which showed that curcumin loaded MNP-based conjugates showed themselves to be a potential agent for application as a bimodal contrast enhancer of magnetic resonance imaging (MRI) and fluorescence imaging.
Abstract: In this paper we first summarize our recent research on fabrication and structure characterization of conjugates of Fe3O4 nanoparticles (MNPs) encapsulated by several organic materials such as oleic acid (OL), starch (ST), dextran (D), chitosan (CS), O-carboxymethyl chitosan (OCMCS) and the copolymer of poly(styrene-co-acrylic acid (St-co-AA)). The ferrofluids stability and toxicity were also considered. The magnetic inductive heating (MIH) curves were measured using a set up with an alternating (ac) magnetic field of strength of 40–100 Oe and frequency of 180–240 kHz. We then present new results dealing with attempting to apply the MNP/copolymer ferrofluid for treatment of Sarcoma 180 tumor. In vitro as well as ex vivo MIH experiments were carried out as preparation steps in order to estimate the proper conditions for the in vivo MIH experiment. As for the latter, we have successfully carried out the treatment of solid tumor of size around 6 × 6 mm inoculated on Swiss mice with use of a dose of 0.3–0.4 mg ml−1 ferrofluid injected subcutaneously into the tumor and field-irradiated for 30 min. Two groups of treated mice recovered in three weeks from MIH treatment three times during the first week. We finally show that curcumin loaded MNP-based conjugates showed themselves to be a potential agent for application as a bimodal contrast enhancer of magnetic resonance imaging (MRI) and fluorescence imaging. Additionally, in vitro and ex vivo studies by these two techniques evidenced that macrophage is capable of uptake and tends to carry the MNPs into a tumor.

15 citations

Journal ArticleDOI
TL;DR: The SPIOs concentrations were verified mainly by magnetic inductive heating measurement with a combination with atomic absorption spectroscopy (AAS) and the results indicated the density detected highest in liver and lowest in kidney.
Abstract: Biodistribution studies provide basic information to design and perform various applications of superparamagnetic iron oxide magnetic nanoparticles (SPIOs) in biomedicine such as drug delivery, MRI as well as hyperthermia. Recently, several quantitative measurements as well as new imaging methods have been used to characterize the SPIOs distribution in organs and in tissues of animal model. In this report we used the fabricated iron oxide nanoparticles coated with two block copolymers of polystyrene-co-polyacrylic acid (St-co-PAA) and polylactic acid-co-polyethylene glycol (PLA-PEG). The biodistributions were investigated ex-vivo for several organs of both healthy and Sarcoma transplanted Swiss mice. The SPIOs concentrations were verified mainly by magnetic inductive heating (MIH) measurement with a combination with atomic absorption spectroscopy (AAS). The results indicated the density detected highest in liver and lowest in kidney. The SPIOs concentration increased significantly up to 24 h after the injection. The observations by our two methods not only are in agreement with each other but also consistent with the tendency reported by other techniques. Discussion will also concern injection strategy for various aspects of hyperthermia applications.

13 citations


Cited by
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Journal ArticleDOI
TL;DR: This review mainly focuses on the influence of spin canting effects, introduced by the variations in size, shape, and organic/inorganic surface coatings, on the magnetic properties of SPIONs.

301 citations

Journal ArticleDOI
TL;DR: This short review presents recent developments in the field of cancer targeted drug delivery using magnetic nanocarriers as drug delivery systems and gives special attention to the pharmacokinetics and in vivo behavior of the developed nanoccarriers.
Abstract: Introduction: For many years, the controlled delivery of therapeutic compounds has been a matter of great interest in the field of nanomedicine. Among the wide amount of drug nanocarriers, magnetic...

298 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present a systematic review of measurement methods for both SAR and ILP, leading to recommendations for a standardised, simple and reliable method for measurements using non-adiabatic systems.
Abstract: In the clinical application of magnetic hyperthermia, the heat generated by magnetic nanoparticles in an alternating magnetic �耀eld is used as a cancer treatment. The heating ability of the particles is quanti�耀ed by the speci�耀c absorption rate (SAR), an extrinsic parameter based on the clinical response characteristic of power delivered per unit mass, and by the intrinsic loss parameter (ILP), an intrinsic parameter based on the heating capacity of the material. Even though both the SAR and ILP are widely used as comparative design parameters, they are almost always measured in non-adiabatic systems that make accurate measurements dif�耀cult. We present here the results of a systematic review of measurement methods for both SAR and ILP, leading to recommendations for a standardised, simple and reliable method for measurements using non-adiabatic systems. In a representative survey of 50 retrieved datasets taken from published papers, the derived SAR or ILP was found to be more than 5% overestimated in 24% of cases and more than 5% underestimated in 52% of cases.

269 citations

Journal ArticleDOI
TL;DR: The constructed rGO/Fe3O4/GCE sensor exhibited excellent electrocatalytic activity toward the electrooxidation of dopamine (DA) with a quick response time of 6s, a wide linear range between 0.01 and 100, high sensitivity and practical applicability in the quantification of DA in urine samples with an excellent recovery rate.

189 citations

Journal ArticleDOI
14 Aug 2018
TL;DR: This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds, and the current development and future perspectives on the use of Electrospun mats inBone tissue engineering.
Abstract: Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

171 citations