Hyuk-Soo Seo

TL;DR: This work identifies ENL as an unrecognized gene that is specifically required for proliferation in vitro and in vivo and suggests a mechanistic rationale for disrupting the YEATS domain in disease.

TL;DR: The first BRD9-directed chemical degraders are created, through iterative design and testing of heterobifunctional ligands that bridge theBRD9 bromodomain and the cereblon E3 ubiquitin ligase complex, and reveal the tractability of non-BET bromidomain containing proteins to chemical degradation.

TL;DR: In this paper, the multidomain, bromodomain-containing transcriptional regulator TRIM24 was used as a chemical probe of an emerging cancer dependency, and established a path forward for numerous selective yet ineffectual ligands for proteins of therapeutic interest.

TL;DR: Three crystal structures of the nucleoporin pair Seh1*Nup85 are reported, which is part of the coat cylinder, which supports the notion that the NPC coat represents another class of membrane coats.

TL;DR: This study combined chemical and genetic perturbants, including the development of a novel selective maternal embryonic leucine zipper kinase (MELK) inhibitor HTH-01-091, CRISPR/Cas9-mediated MELK knockout, and a novel chemical-induced protein degradation strategy, RNA interference andCRISPR interference to validate M ELK as a therapeutic target in basal-like breast cancers.