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Iain M. Wallace
Researcher at University of Toronto
Publications - 31
Citations - 30001
Iain M. Wallace is an academic researcher from University of Toronto. The author has contributed to research in topics: Multiple sequence alignment & Chemogenomics. The author has an hindex of 19, co-authored 31 publications receiving 27605 citations. Previous affiliations of Iain M. Wallace include Novartis & Swiss Institute of Bioinformatics.
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Journal ArticleDOI
Clustal W and Clustal X version 2.0
Mark A. Larkin,Gordon Blackshields,Nigel P. Brown,R. Chenna,Paul A. McGettigan,Hamish McWilliam,Franck Valentin,Iain M. Wallace,Andreas Wilm,Rodrigo Lopez,J.D. Thompson,Toby J. Gibson,Desmond G. Higgins +12 more
TL;DR: The Clustal W and ClUSTal X multiple sequence alignment programs have been completely rewritten in C++ to facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems.
Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
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M-Coffee : Combining multiple sequence alignment methods with T-Coffee
TL;DR: M-Coffee is a meta-method for assembling multiple sequence alignments (MSA) by combining the output of several individual methods into one single MSA that is robust to variations in the choice of constituent methods and reasonably tolerant to duplicate MSAs.
Journal ArticleDOI
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
Andrew M. Smith,Lawrence E. Heisler,Robert P. St.Onge,Eveline Farias-Hesson,Iain M. Wallace,John Bodeau,Adam Harris,Kathleen M. Perry,Guri Giaever,Nader Pourmand,Corey Nislow +10 more
TL;DR: The successful 96-plexing of complex pools of DNA barcoded yeast mutants is reported and it is shown that such ‘Bar-seq’ assessment of these samples is comparable with data provided by barcode microarrays, the current benchmark for this application.
Journal ArticleDOI
Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures
Anna Y. Lee,Robert P. St.Onge,Michael Proctor,Iain M. Wallace,Aaron H. Nile,Paul A. Spagnuolo,Yulia Jitkova,Marcela Gronda,Yan Wu,Moshe K. Kim,Kahlin Cheung-Ong,Nikko P. Torres,Eric D. Spear,Mitchell K. L. Han,Ulrich Schlecht,Sundari Suresh,Geoffrey Duby,Lawrence E. Heisler,Anuradha Surendra,Eula Fung,Malene L. Urbanus,Marinella Gebbia,Elena Lissina,Molly Miranda,Jennifer Chiang,Ana Aparicio,Mahel Zeghouf,Ronald W. Davis,Jacqueline Cherfils,Marc Boutry,Chris A. Kaiser,Carolyn L. Cummins,William S. Trimble,Grant W. Brown,Aaron D. Schimmer,Vytas A. Bankaitis,Corey Nislow,Corey Nislow,Gary D. Bader,Guri Giaever +39 more
TL;DR: This paper used a yeast chemogenomics platform that quantifies the requirement for each gene for resistance to a compound in vivo to profile 3250 small molecules in a systematic and unbiased manner.