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Ian G. Young
Researcher at Australian National University
Publications - 89
Citations - 17959
Ian G. Young is an academic researcher from Australian National University. The author has contributed to research in topics: Interleukin 5 & Gene. The author has an hindex of 44, co-authored 89 publications receiving 17528 citations. Previous affiliations of Ian G. Young include Laboratory of Molecular Biology.
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Journal ArticleDOI
Sequence and organization of the human mitochondrial genome
Stephen Anderson,Alan T. Bankier,Bart Barrell,M.H.L. de Bruijn,Alan Coulson,J. Drouin,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Donald P. Nierlich,Bruce A. Roe,Bruce A. Roe,Frederick Sanger,P. H. Schreier,Andrew J.H. Smith,Rodger Staden,Ian G. Young,Ian G. Young +17 more
TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
TL;DR: Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.
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Recombinant human interleukin 5 is a selective activator of human eosinophil function.
Angel F. Lopez,Colin J. Sanderson,Jennifer R. Gamble,Hugh Campbell,Ian G. Young,Mathew A. Vadas +5 more
TL;DR: Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils, and is thus a prime candidate for the selective eOSinophilia and eos inophil activation seen in disease.
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IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses
Manfred Kopf,Frank Brombacher,Philip D. Hodgkin,Alistair J. Ramsay,Elizabeth A. Milbourne,Wen J Dai,K.S. Ovington,Carolyn A. Behm,Georges Köhler,Ian G. Young,Klaus I. Matthaei +10 more
TL;DR: Mice deficient in interleukin-5 (IL-5-/- mice) were generated by gene targeting in embryonal stem cells, indicating that increased eosinophils do not play a significant role in the host defence in this parasite model.
Journal ArticleDOI
Molecular cloning of cDNA for murine interleukin-3.
Ming Chiu Fung,Andrew J. Hapel,Sanie Ymer,Donna R. Cohen,R. M. Johnson,H. D. Campbell,Ian G. Young +6 more
TL;DR: The predicted amino acid sequence indicates that formation of mature interleukin-3 involves proteolytic removal of not only the signal peptide but additional ammo-terminal amino acids.