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Ian Kasman
Researcher at Genentech
Publications - 30
Citations - 7456
Ian Kasman is an academic researcher from Genentech. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 23, co-authored 30 publications receiving 6966 citations. Previous affiliations of Ian Kasman include University of California, San Francisco & University of California, San Diego.
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Journal ArticleDOI
Interleukin-22, a T H 17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng,Dimitry M. Danilenko,Patricia Valdez,Ian Kasman,Jeffrey Eastham-Anderson,Jianfeng Wu,Wenjun Ouyang +6 more
TL;DR: The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis.
Journal ArticleDOI
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John B. Ridgway,Gu Zhang,Yan Wu,Scott Stawicki,Wei-Ching Liang,Yvan Chanthery,Joe Kowalski,Ryan J. Watts,Christopher A. Callahan,Ian Kasman,Mallika Singh,May Chien,Christine Tan,Jo Anne Hongo,Fred de Sauvage,Greg Plowman,Minhong Yan +16 more
TL;DR: It is shown that Dll4-mediated Notch signalling has a unique role in regulating endothelial cell proliferation and differentiation, and is crucial during active vascularization, but less important for normal vessel maintenance.
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PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
Yongping Crawford,Ian Kasman,Lanlan Yu,Cuiling Zhong,Xiumin Wu,Zora Modrusan,Josh Kaminker,Napoleone Ferrara +7 more
TL;DR: It is shown that platelet-derived growth factor C (PDGF-C) is upregulated in TAFs from resistant tumors and suggested that some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF- C.
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A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
Ruihuan Chen,Merry C. Nishimura,Stephanie M. Bumbaca,Samir Kharbanda,William F. Forrest,Ian Kasman,Joan M. Greve,Robert Soriano,Laurie L. Gilmour,Celina Sanchez Rivers,Zora Modrusan,Serban Nacu,Steve Guerrero,Kyle A. Edgar,Jeffrey Wallin,Katrin Lamszus,Manfred Westphal,Susanne Heim,C. David James,Scott R. VandenBerg,Joseph F. Costello,Scott Moorefield,Cynthia Cowdrey,Michael D. Prados,Heidi S. Phillips,Heidi S. Phillips +25 more
TL;DR: The results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-Renewing cell types expressing a range of markers of forebrain lineage.
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The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
Susan M Sa,Patricia Valdez,Jianfeng Wu,Kenneth Jung,Fiona Zhong,Linda Hall,Ian Kasman,Jane Winer,Zora Modrusan,Dimitry M. Danilenko,Wenjun Ouyang +10 more
TL;DR: It is shown that primary human keratinocytes express receptors for these cytokines and that IL-20 subfamily cytokines induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner.