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Icy D’Silva
Researcher at Laval University
Publications - 2
Citations - 1902
Icy D’Silva is an academic researcher from Laval University. The author has contributed to research in topics: Poly ADP ribose polymerase & DNA. The author has an hindex of 2, co-authored 2 publications receiving 1811 citations.
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Journal ArticleDOI
Poly(adp-ribosyl)ation reactions in the regulation of nuclear functions
TL;DR: The total dependence of poly(ADP-ribose) synthesis on DNA strand breaks strongly suggests that this post-translational modification is involved in the metabolism of nucleic acids, and the presence of PARP in these multiprotein complexes clearly supports an important role for poly(ADE-ribosyl)ation reactions in DNA transactions.
Journal ArticleDOI
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions.
Icy D’Silva,Joëlle D. Pelletier,Jean Lagueux,Damien D'Amours,M.Ahmad Chaudhry,Michael Weinfeld,Susan P. Lees-Miller,Guy G. Poirier +7 more
TL;DR: It is demonstrated that PARP, when compared to DNA-PK, has a greater preference for blunt ends and 3' single-base overhangs but a weaker preference for long overhangers, and nicks are effective in attracting and activating PARP.