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Ifor R. Williams
Researcher at Emory University
Publications - 145
Citations - 17100
Ifor R. Williams is an academic researcher from Emory University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 63, co-authored 145 publications receiving 16060 citations. Previous affiliations of Ifor R. Williams include Davidson College & Harvard University.
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Journal ArticleDOI
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
TL;DR: FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.
Journal ArticleDOI
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.
TL;DR: A population of CD11b+F4/80+CD11c− macrophages in the lamina propria that expressed several anti-inflammatory molecules, including interleukin 10 (IL-10), but little or no proinflammatory cytokines, even after stimulation with Toll-like receptor ligands is described.
Journal ArticleDOI
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
Brian J. P. Huntly,Hirokazu Shigematsu,Kenji Deguchi,Benjamin H. Lee,Shinichi Mizuno,Nicky Duclos,Rebecca Rowan,Sonia M Amaral,David P. Curley,Ifor R. Williams,Koichi Akashi,D. Gary Gilliland,D. Gary Gilliland +12 more
TL;DR: It is demonstrated that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death.
Journal ArticleDOI
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.
Louise M Kelly,Qing Liu,Jeffrey L. Kutok,Ifor R. Williams,Christina L. Boulton,D. Gary Gilliland +5 more
TL;DR: It is demonstrated that FLT3-ITD mutant proteins are sufficient to induce a myeloproliferative disorder, but are insufficient to recapitulate the AML phenotype observed in humans.
Journal ArticleDOI
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
TL;DR: This review highlights how understanding of the factors that influence the development and function of M cells has been used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines.