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Igor A. Schepetkin
Researcher at Montana State University
Publications - 121
Citations - 4639
Igor A. Schepetkin is an academic researcher from Montana State University. The author has contributed to research in topics: Formyl peptide receptor & Agonist. The author has an hindex of 30, co-authored 110 publications receiving 3814 citations. Previous affiliations of Igor A. Schepetkin include Tomsk Polytechnic University & University of Ulsan.
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Botanical polysaccharides: macrophage immunomodulation and therapeutic potential.
Igor A. Schepetkin,Mark T. Quinn +1 more
TL;DR: The evaluation of botanical polysaccharide isolated from a wide array of different species of flora provides a unique opportunity for the discovery of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties.
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Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha
TL;DR: Analysis of the effects of Opuntia polysaccharides on human and murine macrophages demonstrated that all four fractions had potent immunomodulatory activity, inducing production of reactive oxygen species, nitric oxide, tumor necrosis factor alpha, and interleukin 6.
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Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum.
TL;DR: Analysis of the effects of Juniper polysaccharides on murine peritoneal macrophages, cultured J774, and human mononuclear phagocytes suggest that at least part of the beneficial therapeutic effects reported for extracts of juniper cones are due to modulation of monocyte/macrophage immune functions.
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Improved quantitative structure–activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems
TL;DR: This is the first QSAR model derived for description of flavonoid direct/indirect antioxidant effects in a cellular system, and this model could form the basis for further drug development of Flavonoid-like antioxidant compounds with therapeutic potential.
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Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.
TL;DR: The results provide a molecular basis to explain at least part of the beneficial therapeutic effects of Tansy extracts, and support the concept of using TansY polysaccharides as an immunotherapeutic adjuvant.