Igor F. Zhimulev

TL;DR: Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.

TL;DR: An improved reference sequence of the single-copy and middle-repetitive regions of the genome is reported, produced using cytogenetic mapping to mitotic and polytene chromosomes, clone-based finishing and BAC fingerprint verification, ordering of scaffolds by alignment to cDNA sequences, incorporation of other map and sequence data, and validation by whole-genome optical restriction mapping.

TL;DR: A dominant-negative mutant EcR (EcR-DN) is developed, expressed in flies with the GAL4/UAS system, and used to block ecdysone signaling in eight tissues or groups of tissues.

TL;DR: It is proposed that the specific features of intercalary heterochromatin bands are determined by tandem repetitiveness and late replication, which could cause incomplete polytenization of the region and, as a consequence, breaks (or weak points) and the appearance of “adhesive ends” which may take part either in realization of ectopic contacts or in fixation of those occurring previously.

TL;DR: A model for the induction of early ecdysone puffs is proposed, assigning a key role to the 2B5 puff product in stimulating other early puffed, and it is suggested that defects in the activity of early puffs in the mutant t10 may cause underdevelopment of late puffs.