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Igor V. Makunin
Researcher at University of Queensland
Publications - 38
Citations - 5690
Igor V. Makunin is an academic researcher from University of Queensland. The author has contributed to research in topics: Polytene chromosome & Gene. The author has an hindex of 18, co-authored 37 publications receiving 5111 citations. Previous affiliations of Igor V. Makunin include Australian Research Council & Novosibirsk State University.
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Journal ArticleDOI
Non-coding RNA
John S. Mattick,Igor V. Makunin +1 more
TL;DR: RNAs appear to comprise a hidden layer of internal signals that control various levels of gene expression in physiology and development, including chromatin architecture/epigenetic memory, transcription, RNA splicing, editing, translation and turnover.
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Ultraconserved Elements in the Human Genome
Gill Bejerano,Michael Pheasant,Igor V. Makunin,Stuart Stephen,W. James Kent,John S. Mattick,David Haussler +6 more
TL;DR: There are 481 segments longer than 200 base pairs that are absolutely conserved between orthologous regions of the human, rat, and mouse genomes, which represent a class of genetic elements whose functions and evolutionary origins are yet to be determined, but which are more highly conserving between these species than are proteins.
Journal ArticleDOI
Small regulatory RNAs in mammals
John S. Mattick,Igor V. Makunin +1 more
TL;DR: The extent of transcription of non-coding sequences and the abundance of small RNAs suggests the existence of an extensive regulatory network on the basis of RNA signaling which may underpin the development and much of the phenotypic variation in mammals and other complex organisms and which may have different genetic signatures from sequences encoding proteins.
Journal ArticleDOI
The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update
Enis Afgan,Anton Nekrutenko,Björn Grüning,Daniel Blankenberg,Jeremy Goecks,Michael C. Schatz,Alexander E. Ostrovsky,Alexandru Mahmoud,Andrew Lonie,Anna Syme,Anne Fouilloux,Anthony Bretaudeau,Anup Kumar,Arthur C. Eschenlauer,Assunta D. Desanto,Aysam Guerler,Beatriz Serrano-Solano,Bérénice Batut,Bradley W. Langhorst,Bridget Carr,Bryan Raubenolt,Cameron J. Hyde,Catherine J. Bromhead,Christopher B. Barnett,Coline Royaux,Cristóbal L. García Gallardo,Daniel Fornika,Dannon Baker,Dave Bouvier,Dave Clements,David A. de Lima Morais,David Lopez Tabernero,Delphine Larivière,E. Nasr,Federico Zambelli,Florian Heyl,Fotis Psomopoulos,Frederik Coppens,Gareth Price,Gianmauro Cuccuru,Gildas Le Corguillé,Gregory Von Kuster,Gulsum Gudukbay,Helena Rasche,Hans-Rudolf Hotz,Ignacio Eguinoa,Igor V. Makunin,Isuru Ranawaka,James Taylor,Jayadev Joshi,Jennifer Hillman-Jackson,John Chilton,Kaivan Kamali,Keith Suderman,Krzysztof Poterlowicz,Yvan Le Bras,Lucille Lopez-Delisle,Luke Sargent,Madeline E. Bassetti,M. A. Tangaro,Marius Van Den Beek,Martin Čech,Matthias Bernt,Matthias Fahrner,Mehmet Tekman,Melanie Föll,Michael R. Crusoe,Miguel Angel Roncoroni,N. K. Kucher,Nathaniel Coraor,Nicholas Stoler,Nick Rhodes,Nicola Soranzo,Niko Pinter,Nuwan Goonasekera,Pablo Moreno,Pavankumar Videm,Petera Melanie,Pietro Mandreoli,Pratik D. Jagtap,Qiang Gu,Ralf J. M. Weber,Ross Lazarus,Ruben H.P. Vorderman,Saskia Hiltemann,Sergey Golitsynskiy,Shilpa Garg,Simon Bray,Simon Gladman,Simone Leo,Subina Mehta,Timothy J. Griffin,Vahid Jalili,Yves Vandenbrouck,Vi-Kwei Wen,Vijaykrishna Nagampalli,W. Bacon,W. L. De Koning,Wolf-Martin Maier,P. J. Briggs +99 more
TL;DR: Key Galaxy technical developments include an improved user interface for launching large-scale analyses with many files, interactive tools for exploratory data analysis, and a complete suite of machine learning tools.
Journal ArticleDOI
Transposon-free regions in mammalian genomes.
TL;DR: Most TFRs are not associated with unusual nucleotide composition, but are significantly associated with genes encoding developmental regulators, suggesting that they represent extended regions of regulatory information that are largely unable to tolerate insertions, a conclusion difficult to reconcile with current conceptions of gene regulation.